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TranscriptomicsDeregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in BCP-ALL
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia We report two novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32)...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17165 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 at 0.5 to 48 hours after INFg treatment
Timecourse analysis of Interferon-Gamma (IFNg) signalling in mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 (SOCS1).
ORGANISM(S): Mus musculus 
2007-06-27 | E-GEOD-4232 | biostudies-arrayexpress
TranscriptomicscaArray_bonda-00136: Molecular basis of age associated cytokine dysregulation in LPS stimulated macrophages
Aged humans and rodents are susceptible to infection with Streptococcus pneumoniae bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines and increased production of interleukin (IL)-10 by macr...
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-68580 | biostudies-arrayexpress
ProteomicsSecretome analysis (Olink® Target 48 Cytokine panel) of MAIT cell-derived media after the exposure to IL-33, IL-12p70 or their combination
This study intends to explore, by using the Olink® Target 48 Cytokine panel, the secretome derived from human circulating MAIT cells that were exposed to a combination of different stimuli, including IL-33 and IL-12p70.
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PAD000044 | Pride
Mait cells Il-12 Il-33 Alarmins Secretome 
TranscriptomicsmiRNA expression in cytokine-stimulated airway smooth muscle cells
We used microarrays to determine if miRNA expression in human airway smooth muscle cells is altered by a pro-inflammatory stimulus. A majority of the miRNAs on the array exhibited very low signal intensity. In ASM cells exposed to IL-1β, TNFα, and IFNγ, none of the miRNA expressed were signific...
ORGANISM(S): Homo sapiens 
2010-08-17 | E-GEOD-16587 | biostudies-arrayexpress
ProteomicsLongitudinal Olink affinity proteomics profiling of cytokine release syndrome in myeloma patients receiving BCMA-directed CAR-T therapy
This submission contains de-identified Olink NPX affinity proteomics data from longitudinal peripheral blood samples collected from patients with relapsed/refractory multiple myeloma treated with BCMA-directed CAR-T therapy (ide-cel or cilta-cel) in a prospective single-center pilot study. Samples w...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PAD000041 | Pride
Car-t Myeloma Wearables Cytokines Crs 
GenomicsAsymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity
IL-6 and IL-27 have antagonistic and overlapping functions, signal through a shared receptor subunit and employ the same downstream STAT proteins. To evaluate the degree of specificity and redundancy for these cytokines, we quantified global transcriptomic changes induced by the two cytokines and de...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-65621 | biostudies-arrayexpress
ProteomicsCytokine-enhanced cytolytic activity of Exosomes from NK Cells
Natural killer (NK) cells are a type of innate lymphocytes that play key roles in immune surveillance against tumors and viral infection. NK cells distinguish abnormal cells from healthy cells by cell-cell interaction with cell surface proteins and then attack target cells via multiple mechanisms in...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018982 | Pride
Exosome Cytokine Nk cells 
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
ProteomicsGS1 Cytokine Array Analysis of Primary Human Macrophages Polarized to M0, M1, M2, 14P-TAM, and 14P-RT TAM states
A comparative analysis of 20 analytes from matched primary macrophages polarized to various states was performed to characterize a novel polarization method and compare it to classically polarized M0, M1, and M2 macrophages. Macrophages polarized by the xenoline JX14P and its matched in vivo radiati...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-15227 | biostudies-arrayexpress
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