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MetabolomicsMucosal-Associated-Invariant-T (MAIT) cells stimulated with IL-12/IL-12, anti-CD3/CD28 or both for 16 hours
Not available
ORGANISM(S): Homo sapiens 
ST001653 | MetabolomicsWorkbench
TranscriptomicsIL-12 induces myeloid cells in situ to cross-present antigen
Myeloid-derived cells comprising the tumor stroma represent a heterogeneous population of cells critical to the structure, function and growth of established cancers. We have recently found that engineering tumor-specific CD8+ T cells to secrete IL-12 (IL-12TD) can lead to striking improvements in T...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-29164 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human CD8+ T cells: IL-12 and IFN-a polarized in vitro stimulated and ex vivo sorted CCR7hi and CXCR3hi populations
CD8+ cytotoxic T lymphocytes (CTLs) play a major role in defense against intracellular pathogens, and their functions are specified by antigen recognition and innate cytokines. While effector CTLs eliminate the infection, a small population of memory cells are retained that yields more rapid and rob...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-27337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human naive CD8 T cells at 0, 24, 48 and 72h of in vitro culture stimulated with antigen-B7 and with or without IL-12 or IFNa/b
Differentiation of naive CD8 T cells into cytotoxic effector cells requires three distinct signals- antigen (signal 1), costimulation -B7-1 (signal 2) and cytokine, either interleukin-12 or interferon-a/b (signal 3). Interaction of naive CD8 T cells with antigen and B7-1 programs cell division and p...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-15930 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in IL-2, IL-12 and IL-18 stimulated human natural killer cells
We used Affymetrix expression arrays to determine changes in gene expression associated with activation of human NK cells mediated through treatment with cytokines IL-2, IL-12 and IL-18 over a 24 hour period. Human natural killer cells were isolated via negative selection from PBMCs of healthy donor...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-GEOD-22919 | biostudies-arrayexpress
ProteomicsIn-depth analysis of the phosphoprotein landscape of cytotoxic T lymphocytes and its regulation by cytokines
Here we present high-resolution mass spectrometry analysis of changes to the phosphoproteome of cytotoxic T lymphocytes (CTL) induced by the cytokine, Interleukin 12 (IL-12). We treated CTL with a short and long IL-12 stimulation and mapped the changes to the phosphoproteome using quantitative SILAC...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-24 | PXD004644 | Pride
Silac Il-12 Phosphoproteomics Lymphocytes 
TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
GenomicsHuman Treg IL-12 stimulation
Human Treg IL-12 stimulation
PRJNA488425 | ENA
ProteomicsPhosphoproteomic analysis of IL-2 MSA and IL-12 MSA combination on T cell signaling
Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic murine lung tumors were resistant to systemically deli...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD044740 | Pride
Signaling T cell Cytokine 
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