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TranscriptomicsNsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus
S. aureus possesses 16 two-component systems (TCS), two of which (GraRS & NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, conserved within the firmicutes. NsaRS has recently been documented as being important for nisin-resistance in S. aureus. In this study we present a d...
ORGANISM(S): Staphylococcus aureus 
2011-05-16 | E-GEOD-27061 | biostudies-arrayexpress
TranscriptomicsEnterococcus faecalis OG1RF control vs. treatment with ampicillin, bacitracin, or cephalothin
Transcriptional profiling to investigate the effect of drug treatment on the E. faecalis cells. For microarray analysis, E. faecalis OG1RF was grown in FMC medium supplemented with 10 mM glucose to an optical density at 600 nm (OD600) of 0.3 and the cultures were divided in 7 aliquots. One aliquot w...
ORGANISM(S): Enterococcus faecalis OG1RF 
2013-03-16 | E-GEOD-45231 | biostudies-arrayexpress
ProteomicsThe distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana resolve the Central Dogma’s information flow
A label-free proteomics dataset from our investigation of the interplay of constitutive gene-body CpG methylation (gbM), tRNA abundance and codon composition on mRNA and protein expression, in the plant Arabidopsis thaliana. We performed genomic profiling in rosette leaves of two Arabidopsis accessi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-07-31 | PXD058342 | Pride
Dia Arabidopsis Leaf Diapasef Can-0 Col-0 
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsComparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these inf...

2022-09-14 | MTBLS4387 | MetaboLights
ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins
The myosin light chain protein family consists of two classes, the regulatory myosin light chains (RLC) and the essential myosin light chains (ELC). Functionally, the MLC proteins are directly involved in sarcomeric activity and force transmission contributing to cardiac contractility. Besides regul...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD033908 | Pride
Cardiomyocytes Essential myosin light chains (elc) Phosphorylation Regulatory myosin light chains (rlc) 
ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins - proximity labeling
NIMA-related kinase 9 (NEK9) was identified to interact with the essential myosin light chain (ELC). To validate these findings ascorbate peroxidase (APEX) catalyzed proximity labeling (Hung et al. Nat Protoc. 2016) was performed. To do so, human ELC fused to APEX was overexpressed in HEK293 cells. ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD034115 | Pride
Bioid Nek9 Elc 
ProteomicsIdentification of ELC interacting proteins in zebrafish heart
The essential myosin light chain (ELC) is part of the cardiac myosin motor regulating the contractility of the heart. Recently, we have demonstrated ELC phosphorylation to be responsible not only for basal maintenance of cardiac contractility, but also for the adaptation of sarcomere function to inc...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-07-24 | PXD016357 | Pride
Myosin light chain Elc Co-immunoprecipitation Phosphorylation 
UnknownChimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.
Not available
S-EPMC4669850 | biostudies-literature
UnknownImproved cognitive outcomes in patients with relapsing-remitting multiple sclerosis treated with daclizumab beta: Results from the DECIDE study.
Not available
S-EPMC5971365 | biostudies-literature
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