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TranscriptomicsNicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes
Type 2 diabetes (T2D) has become an epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis, and the NAD+-...
ORGANISM(S): Mus musculus 
2011-12-05 | E-GEOD-31647 | biostudies-arrayexpress
TranscriptomicsThe role of nicotinamide phosphoribosyltransferase (Nampt) in hippocampal neural stem/progenitor cells
Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age, but the molecular mechanisms responsible for these declines remain unclear. Here we show that levels of NAD+ and nicotinamide phosphoribosyltransferase (Nampt), ...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-49784 | biostudies-arrayexpress
GenomicsMus musculus
The role of nicotinamide phosphoribosyltransferase (Nampt) in hippocampal neural stem/progenitor cells
PRJNA214888 | ENA
GenomicsMus musculus
mSirt1 overexpression and knockdown in a pancreatic beta-cell line
PRJNA91213 | ENA
TranscriptomicsResveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance
Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in non-obese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of re...
ORGANISM(S): Homo sapiens 
2013-01-02 | E-GEOD-41168 | biostudies-arrayexpress
ProteomicsAge-Related Disruption of the Proteome and Acetylome in Mouse Hearts Correlates with Differential Loss of Function that is Attenuated by SS-31 and NMN
We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs SS-31 and NMN to reverse age-related changes, in mouse hearts. Both drugs had a modest effect on restoring the abundance and acetylation of proteins that are lost with ag...
ORGANISM(S): Mus Musculus 
2022-08-02 | PXD027458 | panorama
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