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TranscriptomicsImipramine Blue: A potent therapeutic regimen that suppresses breast cancer growth and metastasis
Imipramine Blue a novel inhibitor that we recently synthesiszed suppressed breast cancer growth and progression by silencing FOXM1 and its associated signaling. Breast cancer cell-line MDA-MB-231 treated with vehicle (DMSO) and IB, with 2 biological replciates each.
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-72363 | biostudies-arrayexpress
TranscriptomicsMolecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression
Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to fi...
ORGANISM(S): Rattus norvegicus 
2015-07-02 | E-GEOD-56028 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of human breast cancer cell lines MCF7 and MDA-MB-231 treated with imipramine compared to untreated controls
Imipramine, a tricyclic antidepressant, has demonstrated antitumoral properties in various preclinical studies (both in vitro and in vivo), although it is not currently approved for cancer treatment. The aim of this experiment is to investigate the transcriptomic changes associated with imipramine t...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-15351 | biostudies-arrayexpress
ProteomicsImipramine affects the expression of proteins involved in oxidative stress and immunity in rat primary glial cell culture
Glial cells (microglia and astrocytes) have recently became appreciated as an important target for antidepressant drugs. Here we report on the results of comprehensive proteomic analysis of the alteration in protein profile of rat primary mixed glial culture exposed to imipramine. Two-dimensional di...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-17 | PXD007977 | Pride
Imipramine  mixed glial cell culture  microglia  proteome  2d-dige 
TranscriptomicsTranscription profiling of rat nucleus accumbens shell shows CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
We are comparing the gene expression patterns from rats in which they are either double housed or socially isolated. Within these groups we performed the following manipulations:

AAV-GFP to the NAc shell

AAV-CREB to the NAc shell

chronic imipramine treatment

water contro...
ORGANISM(S): Rattus norvegicus 
2009-01-01 | E-MEXP-1944 | biostudies-arrayexpress
TranscriptomicsGene expression of 7 day combinatorial yohimbine and imipramine treated rat hippocampi
Rats treated on 7 consecutive days with either 2 injections of vehicle (Ctl) (DMSO for yohimbine, saline for imipramine) or Y+I (2mg/kg Yohimbine + 20mg/kg Imipramine) were sacrificed 2 hours post the last injection and their hippocampi used for gene expression analysis. Agilent one-color experiment...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-GEOD-61301 | biostudies-arrayexpress
TranscriptomicsKetamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles
Background: Examining transcriptional regulation by existing antidepressants in key neural circuits implicated in depression, and understanding the relationship to transcriptional mechanisms of susceptibility and natural resilience, may help in the search for new therapeutics. Further, given the het...
ORGANISM(S): Mus musculus 
2016-07-27 | E-GEOD-81672 | biostudies-arrayexpress
TranscriptomicsEpigenetic effects of antidepressants to neuroprotective genes in neuronal cultured cells
Antidepressants are widely used for treatment of depression. Imipramine, a typical antidepressant, is recently known to have an effect to restore the expression of brain-derived neurotrophic factor gene, which is decreased in depressed patients, by increasing histone acetylation. However, it is larg...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-63005 | biostudies-arrayexpress
GenomicsGene expression profile of human colorectal carcinoma HCT 116 cell line treated with imipramine
Gene expression profile of human colorectal carcinoma HCT 116 cell line treated with imipramine
PRJNA515465 | ENA
TranscriptomicsGene expression of 7 day combinatorial yohimbine and imipramine treated rat hippocampi
Rats treated on 7 consecutive days with either 2 injections of vehicle (Ctl) (DMSO for yohimbine, saline for imipramine) or Y+I (2mg/kg Yohimbine + 20mg/kg Imipramine) were sacrificed 2 hours post the last injection and their hippocampi used for gene expression analysis.
ORGANISM(S): Rattus norvegicus 
2015-12-31 | GSE61301 | GEO
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