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MetabolomicsMulti-Omics Profiling Reveals Sex-Stratified Biomarkers Predicting Chronicity in Pediatric Primary Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is recognized as an acquired autoimmune hemorrhagic disorder distinguished by diminished platelet counts. The efficacy of a sex-stratified multi-omics integrative analytical strategy for forecasting pediatric ITP chronicity was proposed and validated in this ...

2025-09-01 | MTBLS12920 | MetaboLights
TranscriptomicsDifferences in gene expression and cytokines levels between newly diagnosed and chronic pediatric immune thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves but in some it becomes chronic. To investigate whether the two forms of the disease are similar or separate entities we performed DNA microarray analysis...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-46922 | biostudies-arrayexpress
TranscriptomicsMicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-43179 | biostudies-arrayexpress
TranscriptomicsMatthieuMAHEVAS
Splenic tissues from immune thrombocytopenia purpura (ITP) patients splenectomized after primary failure of treatment with the B-cell depleting agent rituximab were analyzed, and antibody-secreting cells were identified as the major B-cell population resisting the treatment. The phenotype, antibody ...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-MEXP-3711 | biostudies-arrayexpress
ProteomicsPlatelet Proteomics to Understand the Pathophysiology of Immune Thrombocytopenia: Studies in Mouse Models
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by enhanced platelet clearance and defective platelet production. Diagnosis by exclusion and “trial-error” treatment strategies are common practice, and despite the advancement conferred by Thrombopoietin receptor agonists (TPO-RA´...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD028814 | Pride
Immune thrombocytopenia Platelets Pre-clinical mouse models Bottom-up proteomics 
ProteomicsSerum Proteomics of Severe Fever with Thrombocytopenia Syndrome Patients
Dabie bandavirus, also termed as severe fever with thrombocytopenia syndrome virus (SFTSV), was first isolated in China in 2010. At this time, the virus was found to have spread to South Korea, Japan, and other countries. A high case fatality rate is reported for SFTS, ranging from 12–50% within var...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD033989 | Pride
Sfts Serum proteomics Sftsv Lc-ms/ms 
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsAntibody mRNA-seq repertoire sequencing to study relapses after B-cell depletion therapy
Rituximab (RTX) is widely used as a first-line therapeutic strategy for patients affected by immune thrombocytopenia (ITP). However, a large proportion of patients relapse after successful treatment. The present NGS assay was done to help find the cause for this relapse on the immune repertoire leve...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9953 | biostudies-arrayexpress
Proteomicsimmune thrombocytopenia in sitosterolemia is driven by lipid disorder and not proteomic aberrations
Sitosterolemia is a rare autosomal-recessive genetic disorder in which patients develop hypercholesterolemia, and abnormal hematologic and/or liver function tests. In this disease, dysfunction of either ABCG5 or ABCG8 results in intestinal hyperabsorption of all sterols, including cholesterol and mo...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041248 | Pride
Sitosterolemia Platelet proteomics 
GenomicsLow-dose decitabine modulates T cell homeostasis and restores immune tolerance in immune thrombocytopenia
Low-dose decitabine modulates T cell homeostasis and restores immune tolerance in immune thrombocytopenia
PRJNA647271 | ENA
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