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ProteomicsQuantitative proteomic analysis of SFTSV infected THP-1 cells
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing a high fatality of 12-50% in infected patients. In-depth understanding of the SFTSV induced pathogenesis mechanism is critical for developing effective anti-SFTS therapeutics.
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD017224 | Pride
Sftsv Thp-1 cells Quantitative proteomics 
ProteomicsTranscriptional and proteomic dynamics of severe fever with thrombocytopenia syndrome virus infection in Rhipicephalus microplus cells identify antiviral host factors.
Ticks are vectors of arboviruses in many parts of the world. The rising incidence and emergence of tick-borne arboviral infections across human populations indicates that further transmission control strategies including those based on vectors, will be required to reduce the burden of disease. Howev...
ORGANISM(S): Severe fever with thrombocytopenia syndrome virus Rhipicephalus microplus Bunyavirales 
2025-05-26 | PXD052311 | Pride
Sftsv Ap-ms/ms Rhipicephalus microplus Severe fever with thrombocytopenia syndrome 
GenomicsSFTSV infection in the mouse cornea
SFTSV infection in the mouse cornea
PRJNA1522075 | ENA
GenomicsADAR1 Regulates SFTSV Replication by Modulating miRNA Expression
ADAR1 Regulates SFTSV Replication by Modulating miRNA Expression
PRJNA1209045 | ENA
TranscriptomicsSFTSV infection in the mouse cornea
Mouse corneal tissues were infected with SFTSV, and then the corneal tissues were subjected to scRNA-seq analysis.
ORGANISM(S): Mus musculus 
2026-09-06 | GSE345831 | GEO
GenomicsEffect of EGR1 on gene expression during SFTSV-infeced HUVECs
Effect of EGR1 on gene expression during SFTSV-infeced HUVECs
PRJNA1011291 | ENA
ProteomicsDevelopment of functional anti-Gn nanobodies specific for SFTSV based on next generation sequencing and proteomics
Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by novel bunyavirus (SFTSV), with a mortality rate of 6.3% ~ 30%. To date, there is no specific treatment for SFTS. Previously, our studies demonstrate that SFTSV surface glycoprotein (Glycoprotein N, Gn) is a p...
ORGANISM(S): Camelidae 
2024-01-26 | PXD032731 | Pride
Lc ms/ms Nanobody Camel 
TranscriptomicsSFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication
In this study, transcriptomic profiling identified PPM1K as a prominently induced host factor in SFTSV-infected THP-1 cells. We further demonstrate that SFTSV infection promotes endoplasmic reticulum–mitochondria coupling, enabling the viral glycoprotein GC to interact with mitochondrial PPM1K and e...
ORGANISM(S): Homo sapiens 
2026-04-21 | GSE328306 | GEO
GenomicsADAR1 Regulates SFTSV Replication by Modulating miRNA Expression
RNA modification plays a crucial role in the regulation of various diseases and viral infections. ADAR1 (adenosine deaminase 1) is a key RNA editing enzyme that can convert adenosine (A) into the modified base inosine (I). This RNA modification has been confirmed to regulate the biological processes...
ORGANISM(S): Homo sapiens 
2026-01-07 | GSE286388 | GEO
UnknownAntibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV.
Not available
S-EPMC10486111 | biostudies-literature
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