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ProteomicsBTN2A1 Targeting Reprograms M2-like Macrophages and TAMs via SYK and MAPK Signaling
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across diverse cancer types. We developed anti-BTN2A1 monoclonal antibod...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD055262 | Pride
Lc-msms Ap-ms Butyrophilin (btn)2a1 Reprogramming Mapk Immunosuppressive m2-like Syk Cancer 
TranscriptomicsInduction of regulatory M2 macrophage-like immunosuppressive cells from mouse ES cells that contribute to prolong allogeneic immune rejection
A promise of cell replacement therapy using pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) as donor source has been increased. However, particularly when ESCs were used, immune suppression should be required because the donor-recipient com...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-56302 | biostudies-arrayexpress
UnknownCCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness.
Not available
S-EPMC12948957 | biostudies-literature
UnknownImmunoglobulin-like transcript 5 polarizes M2-like tumor-associated macrophages for immunosuppression in non-small cell lung cancer.
Not available
S-EPMC11970544 | biostudies-literature
TranscriptomicsPERK is a critical metabolic hub for immunosuppressive function in macrophages
Here we report that the Th2 cytokine IL-4 and the tumor microenvironment activated protein kinase RNA-like ER kinase (PERK) ER stress signaling cascade to promote immunosuppressive M2 activation and proliferation. Lacking PERK signaling impeded mitochondrial respiration and lipid oxidation critical ...
ORGANISM(S): Mus musculus 
2022-01-01 | GSE165836 | GEO
UnknownCPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage.
Not available
S-EPMC11093039 | biostudies-literature
GenomicsPERK is a critical metabolic hub for immunosuppressive function in macrophages
PERK is a critical metabolic hub for immunosuppressive function in macrophages
PRJNA698226 | ENA
TranscriptomicsTargeting PHGDH reverses the immunosuppressive function in macrophages and enhances cancer immunotherapy
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in facilitating macromolecule synthesis, neutralizing oxidative stress, and regulating methylation reactions in cancer cells, lymphocytes, and endothelial cells. However, the role of PHGDH in tumor-associated macrophages (TAMs) r...
ORGANISM(S): Mus musculus 
2024-01-27 | GSE236357 | GEO
UnknownTargeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance.
Not available
S-EPMC10858952 | biostudies-literature
UnknownReprogramming of PD-1+ M2-like tumor-associated macrophages with anti-PD-L1 and lenalidomide in cutaneous T cell lymphoma.
Not available
S-EPMC10371344 | biostudies-literature
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