Sort   by:  
 Page size 
Characterisation of induced motor neurons (iMN) generated from human induced pluripotent stem cells (hiPSC, hPSCreg name BIHi005-A) using doxycycline inducible expression of Ngn2, Isl1 and Lhx3. While this method of iMN generation has been described before (REF: doi.org/10.1002/cpcb.51), no extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD031066 | Pride
Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming (iMN)
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in e...
ORGANISM(S): Mus musculus 
Our understanding of the pathogenesis of idiopathic membranous nephropathy is limited by an incomplete molecular characterization of the cell types in the kidney and interaction between the cells. Besides, the reason for the heterogeneity of these patients as well as the variety of clinical outcomes...
ORGANISM(S): Homo sapiens 
2021-05-30 | GSE171458 | GEO
We characterized the renal parenchymal cell and immune cell profiles of IMN renal tissues and discovered the distinct expression signatures of myeloid cell, T cell and B cell subsets.
ORGANISM(S): Homo sapiens 
2023-09-27 | GSE241302 | GEO
Idiopathic Membranous Nephropathy (IMN) is a pathologically defined disorder of the glomerulus, primarily responsible for nephrotic syndromes (NS) in nondiabetic adults. The underlying molecular mechanisms are still not completely clarified. To explore possible molecular and functional signatures, a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-29 | MSV000092309 | MassIVE
Sort   by:  
 Page size