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MetabolomicsMetabolic reaction network-based recursive metabolite annotation for untargeted metabolomics (Aging fruit fly negative mode)

Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network (MRN)-based recursive algorithm (MetDNA) that expands metabolite annotations without the need for a comprehensive standard...

2019-03-26 | MTBLS615 | MetaboLights
MetabolomicsMetabolic reaction network-based recursive metabolite annotation for untargeted metabolomics (Aging fruit fly positive mode)

Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network (MRN)-based recursive algorithm (MetDNA) that expands metabolite annotations without the need for a comprehensive standard...

2019-03-22 | MTBLS612 | MetaboLights
TranscriptomicsTranscriptional profiling of fruit flies overexpressing the Atg1 gene
Overexpression of Atg1 using either weaker CGGAL4 or stronger HRGAL4 driver. Both drivers have same expression pattern and are specific for intestine, Malpighian tubules and fat body of the fruit fly Drosophila melanogaster. Weaker Atg1 overexpression results in longer lifespan whereas stronger Atg1...
ORGANISM(S): Drosophila melanogaster 
2020-07-15 | E-MTAB-9391 | biostudies-arrayexpress
TranscriptomicsViral small RNAs from Drosophila melanogaster flies infected with FHVdeltaB2 or FHV.
We focus our analyses on the description of viral small RNAs (FHVdeltaB2 or FHV) and based on genetic and molecular evidende, classify them and discuss their relevance in antiviral defense. Small RNAs from adult Drosophila flies from different genetic backgrounds and infected with FHV-deltaB2 or FHV...
ORGANISM(S): Drosophila melanogaster 
2011-11-12 | E-GEOD-32011 | biostudies-arrayexpress
TranscriptomicsA Dicistrovirus-specific inducible antiviral response in Drosophila
The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms of innate immunity, and has led to some important discoveries on the sensing and signalling of microbial infections. The response of drosophila to virus infections remains poorly characterized, and appears to i...
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-31542 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of intestinal tissue from Drosophila w1118 and p38c null mutation flies
We investigated changes in transcriptome of Drosophila female guts in wild-type (w1118) flies and p38c mutant flies (p38c7B1) aged 3-5 days.
ORGANISM(S): Drosophila melanogaster 
2014-09-30 | E-MTAB-2740 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [Affymetrix]
Jarid2 was recently identified as an important component of the mammalian Polycomb Repressive Complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved in Drosophila, it has not previously been implicated in Polycomb (Pc) regulation...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36038 | biostudies-arrayexpress
ProteomicsProteome of Yki-driven intestinal stem cell tumors in Drosophila midgut
The experiment was undertaken to characterize Yki-driven intestinal stem cell tumor proteome from Drosophila adult midguts, and to identify changes in the ISC tumor proteome in flies fed on TONDU peptide, using LC MS/MS approach. esgts>UAS-yki3SA flies on day 1, day 7 of tumor induction; TONDU-pepti...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-01-25 | MSV000084841 | MassIVE
TranscriptomicsGene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster
Selenium (Se) is an important trace element for many organisms and is incorporated into selenoproteins as selenocysteine (Sec). In eukaryotes, selenophosphate synthetase SPS2 is essential for Sec biosynthesis. In recent years, genetic disruptions of both Sec biosynthesis genes and selenoprotein gene...
ORGANISM(S): Drosophila melanogaster 
2016-04-06 | E-GEOD-79924 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on SOLiD platform of DrosDel deficiency and w1118 flies
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the SOLiD platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform_technical re...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31401 | biostudies-arrayexpress
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