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ProteomicsMimic miR-497a-5p in vivo intervention
The use of microRNA mimics to increase microRNA levels in the developing organs of newborn mice. Livers from mice treated with 100 mg/kg of an in vivo miR-497a-5p LNA mimic at postnatal day (P)1 and P3 were harvested at postnatal day (P)5. Lungs and livers from mice treated with daily 10 mg/kg in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-13 | PXD053069 | Pride
Microrna Development In vivo mimic 
Transcriptomics21T series cell lines show distinct stage-specific gene expression alterations
Pathologic and epidemiologic evidence has led to a histologic model of breast cancer progression that involves advancement through specific morphologic stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily a...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-18370 | biostudies-arrayexpress
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (gene expression)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42669 | biostudies-arrayexpress
TranscriptomicsMouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.
Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress
GenomicsMnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy
MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy
PRJNA1164802 | ENA
GenomicsDirect-induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplant in vivo
Direct-induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplant in vivo
PRJNA824530 | ENA
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
GenomicsDNA mimic foldamers affect chromatin composition and disturbs cell cycle progression
DNA mimic foldamers affect chromatin composition and disturbs cell cycle progression
PRJNA993228 | ENA
GenomicsProfiling in vivo Bone Lesion and ex vivo Bone-In-Culture Array Samples by Next-Generation Sequencing
Profiling in vivo Bone Lesion and ex vivo Bone-In-Culture Array Samples by Next-Generation Sequencing
PRJNA328044 | ENA
GenomicsExpression data from mouse skin treated with a miR-29 mimic or a miR-29 inhibitor
Expression data from mouse skin treated with a miR-29 mimic or a miR-29 inhibitor
PRJNA438999 | ENA
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