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TranscriptomicsModeling tumor subtypes in vivo using lineage restricted transgenic shRNA
Expression analysis from two genetically engineered mouse models of osteosarcoma determine the expression profile of mouse osteosarcoma Human osteosarcoma (OS) is comprised of three different subtypes: fibroblastic, chondroblastic and osteoblastic. We previously generated a mouse model of fibroblast...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-38742 | biostudies-arrayexpress
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsDifferential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer model (SNP)
The cellular heterogeneity of one patient derived orthotopic breast cancer xenograft model PDX was investigated using flow cytometry, combined with assessment of in vivo tumorigenicity and SNP genotyping array for copy number analysis. Epithelial cell adhesion molecule (EpCAM) was revealed as a high...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-54595 | biostudies-arrayexpress
TranscriptomicsLuminal-like and basal-like in vivo breast cancer xenograft models
The number of relevant and well-characterized cell lines and xenograft models for studying human breast cancer are few, and may represent a limitation for this field of research. With the aim of developing new breast cancer model systems for in vivo studies of hormone dependent and independent tumor...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-23041 | biostudies-arrayexpress
ModelsJarrett2018 - trastuzumab-induced immune response in murine HER2+ breast cancer model
The paper describes a model on the trastuzumab-induced immune response in murine(mouse) HER2+ breast cancer. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical modelling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer A...
2024-09-02 | BIOMD0000000745 | BioModels
Immuno-oncology 
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsLNCaP Atlas: Gene expression associated with in vivo progression to castration-recurrent prostate cancer
Background: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. Methods: We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC in vivo using replicate LongSAGE libraries. We refer ...
ORGANISM(S): Homo sapiens 
2010-09-26 | E-GEOD-18402 | biostudies-arrayexpress
TranscriptomicsContribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system
We investigated the specific interactions of the most dominant bacterial CF-pathogen, Pseudomonas aeruginosa, and the anaerobic bacterium Veilllonella parvula, that has been recovered at comparable cell numbers in the respiratory tract of CF patients. We used our recently established in-vivo murine ...
ORGANISM(S): Veillonella parvula DSM 2008 
2014-11-06 | E-GEOD-58388 | biostudies-arrayexpress
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
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