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TranscriptomicsThe Rpd3 Core Complex is a Chromatin Stabilization Module
The S. cerevisiae Rpd3 large (Rpd3L) and small (Rpd3S) histone deacetylase (HDAC) complexes are prototypes for understanding transcriptional repression in eukaryotes [1]. The current view is that they function by deacetylating chromatin, thereby limiting accessibility of transcriptional factors to t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-01 | E-GEOD-33829 | biostudies-arrayexpress
TranscriptomicsGenome-wide maps of primary and processed start-sites of transcripts revealed mechanism controlling in vivo stoichiometry of protein complex in bacteria
Here a differential mRNA-sequencing (dRNA-Seq) strategy was employed to distinguish transcriptional start-sites (TSs) and post-transcriptional processed sites (PSs) of transcripts in the cellulolytic mesophile Clostridium cellulolyticum. PS-harboring genes usually  encode heteromultimeric complexes...
ORGANISM(S): [Clostridium] cellulolyticum 
2015-04-27 | E-GEOD-57652 | biostudies-arrayexpress
ProteomicsEvaluating protein crosslinking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers that seed toxic aggregates. Considerable resear...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-17 | PXD047030 | Pride
Cross-linking Pharmacological chaperone Amyotrophic lateral sclerosis (als) Stabilization Sod1 
GenomicsThe Rpd3 Core Complex is a Chromatin Stabilization Module
The S. cerevisiae Rpd3 large (Rpd3L) and small (Rpd3S) histone deacetylase (HDAC) complexes are prototypes for understanding transcriptional repression in eukaryotes [1]. The current view is that they function by deacetylating chromatin, thereby limiting accessibility of transcriptional factors to t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-01 | GSE33829 | GEO
ProteomicsIn vivo trapping of proteins interacting with the chloroplast CLPC1 chaperone
The chloroplast stromal CLP protease system is essential for growth and development. It consists of a proteolytic CLP core complex that likely dynamically interacts with oligomeric rings of CLPC1, CLPC2 or CLPD AAA+ chaperones. These ATP-dependent chaperones are predicted to bind and unfold CLP prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-05-14 | PXD013494 | Pride
In vivo trapping-proteins interaction- chloroplast - clpc1 chaperone 
ProteomicsIn vivo trapping of proteins interacting with the chloroplast CLPC1 chaperone; potential substrates and adaptors
The chloroplast stromal CLP protease system is essential for growth and development. It consists of a proteolytic CLP core complex that likely dynamically interacts with oligomeric rings of CLPC1, CLPC2 or CLPD AAA+ chaperones. These ATP-dependent chaperones are predicted to bind and unfold CLP prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-10 | PXD013424 | Pride
Clpc1 chaperone in vivo trapping adaprotr substrate 
UnknownThe Rpd3 core complex is a chromatin stabilization module.
Not available
S-EPMC3758238 | biostudies-literature
TranscriptomicsPPARg agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; however, the underlying mechanisms remain unclear. Here we show that PPARγ ligands require full agonism to induce a brown...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-35011 | biostudies-arrayexpress
UnknownFast peptide exchange on major histocompatibility complex class I molecules by acidic stabilization of a peptide-empty intermediate.
Not available
S-EPMC9669992 | biostudies-literature
GenomicsSaccharomyces cerevisiae
The Rpd3 Core Complex is a Chromatin Stabilization Module
PRJNA148203 | ENA
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