Sort   by:  
 Page size 
ProteomicsIn-bone digestion as a way to characterization of human maxillary and mandibular bone tissues
The project is based on in-bone digestion of proteins by trypsin directly in human maxillary and mandibular healthy and pathological bone samples without the prior reduction and alkylation of the disulfide bonds. The released peptides were then separated and identified by LC-MS/MS method.
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD026775 | Pride
In-bone digestion Mandibular bone Oral surgery Maxillary bone Tandem mass spectrometry 
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
ProteomicsDirect in-bone protein digestion with subsequent LC separation and trapped ion mobility MS detection of released peptides as an effective tool for the proteomic characterization of bone tissues
Common pathological changes in bone tissues like osteomas or exostoses remain not fully understood at the molecular level due to the difficulties in analyzing bone tissues in which they occur. Therefore, new rapid and powerful techniques are needed that could become routine tools for such analysis. ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD065656 | Pride
Skull base surgery Oral surgery In-bone peptide separation Osteomas Exostosis 
TranscriptomicsAssociation between in vivo bone formation and ex vivo migration capacity of human bone marrow stromal cells
Introduction: There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplantation studies, only a limited number of hBMSC home to injured tissues sugges...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69358 | biostudies-arrayexpress
TranscriptomicsGene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray
Osteoarthritis (OA) is a complex degenerative joint disease, which is not only a cartilage but also a bone disease. A better understanding of the early molecular mechanism changes of subchondral bone in vivo may contribute to elucidating the pathogenesis of OA. We used microarray technology to inves...
ORGANISM(S): Rattus norvegicus 
2012-12-11 | E-GEOD-30322 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling analysis of bone metastases of human non-small cell lung cancer (NSCLC) in mice
Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-29391 | biostudies-arrayexpress
ProteomicsBispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose accumulation in experimental chronic kidney disease
Chronic kidney disease (CKD) leads to bone loss and bone marrow adipose tissue (BMAT) accumulation. Sclerostin and dickkopf-1 (DKK1) are two inhibitors of Wnt signalling, which suppress bone formation, promote bone marrow adipogenesis, and are elevated in CKD. However, therapies targeting sclerostin...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD069117 | Pride
Bone Chronic kidney disease (ckd) 
ProteomicsProteome variation with collagen yield in ancient bone
Isotope analyses are some of the most common analytical methods applied to ancient bone, aiding the interpretation of past diets and chronology. For this, the evaluation of “collagen” yield is a routine step that allows for the selection of the specimens that are adequate for subsequent analyses, an...
ORGANISM(S): Bos taurus (Bovine) Cervus elaphus (Red deer) Homo sapiens (Human) Equus caballus (Horse) 
2021-02-08 | PXD020516 | Pride
Proteomics  ancient bone  collagen  ncps  radiocarbon dating  stable isotopes. 
TranscriptomicsPredicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7210 | biostudies-arrayexpress
TranscriptomicsPrevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis (PC) lung infection
IFrag-/- but not RAG-/- mice develop rapidly progressing bone marrow failure in response to PC lung infection. Changes contributing to accelerated bone marrow cell apoptosis in IFrag-/- mice appear to be initiated around day 7 post infection. To gain further insight into the mechanism underlying the...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-27835 | biostudies-arrayexpress
Sort   by:  
 Page size