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MetabolomicsComparison of popular enrichment methods for untargeted in vitro metabolomics.

Introduction

Untargeted metabolomics is a popular method by which researchers measure a large portion of the metabolites present in a biological system at once. This approach usually results in complex data sets containing tens to hundreds of thousands of observations whi...

2025-08-11 | MTBLS12332 | MetaboLights
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
MetabolomicsGut Microbiota-Mediated Conversion of Coenzyme A in Vitro

The bacterium Roseburia inulinivorans harbors enzymes predicted to be involved in coenzyme A (CoA) metabolism. To experimentally validate the source of pantetheine, we performed an in vitro co-culture of R. inulinivorans with CoA and analyzed metabolomic profiles. The results demonstrated a signi...

2025-10-15 | MTBLS13143 | MetaboLights
MetabolomicsAssessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights
MetabolomicsImpact of in vitro hormone treatments on the bibenzyl production of Radula complanata (Untargeted metabolomics)

Bibenzyls are a specialized metabolite class found throughout the plant kingdom. One of the most prolific producers of bibenzyls are liverworts, specifically plants of the Radula genera. These plants possess an incredible diversity of bibenzyls, prenylated bibenzyls and a few (bis)bibenz...

2024-01-10 | MTBLS3563 | MetaboLights
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
MetabolomicsTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole

Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the start of the century, and sustainable...

2021-11-02 | MTBLS2559 | MetaboLights
MetabolomicsTargeted LC-MS/MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant (tryptophan and short-chain fatty acid panels)
Targeted LC-MS/MS (MRM) metabolomics of in vitro cultured Rothia mucilaginosa:a tryptophan-pathway panel and a short-chain fatty acid panel comparing culture supernatant with medium controls. Raw mzML files are deposited.
2026-10-06 | MTBLS15044 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant and pellet samples
This study reports untargeted LC-MS metabolomics data from in vitro culture of Rothia mucilaginosa (BNCC363031). A total of 13 biological samples were analyzed, including culture supernatant samples (S1-S5), bacterial pellet samples (B1-B5), and uninoculated medium controls (M1-M3). Data were acquir...
2026-10-06 | MTBLS14792 | MetaboLights
MetabolomicsMass spectrometry based metabolomics for in vitro systems pharmacology: Pitfalls, challenges, and computational solutions

INTRODUCTION: Mass spectrometry based metabolomics has become a promising complement and alternative to transcriptomics and proteomics in many fields including in vitro systems pharmacology. Despite several merits, metabolomics based on liquid chromatography mass spectrometry (LC...

2017-08-23 | MTBLS401 | MetaboLights
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