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TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dendritic cell differentiation from dendritic cell progenitor in vitro
FLT3+CD11b+ DC progenitor was amplified in vitro from mouse bone marrow. DC were differentiated using GM-CSF and analyzed at day 7 and day 10 of differentiation and after 16h TNFalpha stimulation at day 10
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-575 | biostudies-arrayexpress
GenomicsComparison of intimal and medial calcification in vitro
Comparison of intimal and medial calcification in vitro
PRJNA872009 | ENA
ProteomicsApoC-III is a novel inducer of human valvular calcification
Pharmacological interventions to treat valvular calcification are not currently part of clinical guidelines. Low-density lipoprotein lowering therapies to treat calcific aortic valve disease (CAVD) failed in clinical trials. However, apolipoproteins are known promotors of atherosclerosis and may pla...
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD021858 | Pride
Calcific aortic valve disease  valvular interstitial cells  fibrosis  lipids  apoc-iii 
UnknownIn vitro model assesses the susceptibility of polymeric scaffolds for material-driven heart valve regeneration to calcification.
Not available
S-EPMC12283539 | biostudies-literature
ProteomicsCrenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification
Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD029632 | Pride
Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics 
GenomicsEffect of ADAR1 and MDA5 knock down by siRNA on human SMC phenotypic modulation and calcification in vitro
Effect of ADAR1 and MDA5 knock down by siRNA on human SMC phenotypic modulation and calcification in vitro
PRJNA1072104 | ENA
ProteomicsNuclear factor 90 isoform of vascular smooth muscle cells accelerates diabetic arteriosclerotic calcification by mediating FBXW7-AGER1-AGEs axis
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the prolonged accumulation of advanced glycation end products (AGEs) induced by hyperglycemia may be closely related to the pathogenesis of aortic calcification. However, the mechanisms underlying this assoc...
ORGANISM(S): Homo Sapiens 
2024-04-02 | PXD048707 |
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
ProteomicsProteomic characterization of extracellular vesicles (EVs) released by primary human vascular smooth muscle cells (VSMCs) under calcification stress
Vascular calcification (VC) is a strong predictor of cardiovascular risk, particularly in chronic kidney disease (CKD) patients, associated with increased vascular stiffness, pulse pressure, left ventricular hypertrophy and atherosclerotic plaque burden [1]. VC is currently accepted as a highly cont...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044045 | Pride
Human  vascular smooth muscle cells (vsmcs)  vascular calcification  lc-msms 
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