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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
UnknownIn Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients.
Not available
S-EPMC6750005 | biostudies-literature
ProteomicsDefining the cardiac fibroblast secretome in the post-MI heart in vivo
Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-sta...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-25 | PXD053791 | Pride
Intercellular crosstalk Proteomics Turboid Myocardial infarction In vivo secretome 
Proteomics3 days injured in vivo ASCs proteome
Muscle Stem Cells or satellite cells (SCs) are required for muscle regeneration. In resting muscles, SCs are kept in quiescence. After injury, SCs undergo rapid activation, proliferation and differentiation to repair damaged muscles. The transcriptome alteration during SC activation is well characte...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD023656 | Pride
Timstof Mouse activated muscle stem cells 
ProteomicsThe SILAC fly allows for accurate protein quantification in vivo
Stable isotope labeling by amino acids in cell culture (SILAC) is widely used to quantify protein abundance in tissue culture cells. Until now, the only multicellular organism completely labeled at the amino acid level was the laboratory mouse. The fruit fly Drosophila melanogaster is one of the mos...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-10-12 | PXD003040 | Pride
Silac In vivo Drosophila 
ProteomicsQuantitative analysis of in vivo methionine oxidation of the human proteome
A novel stable isotope labelling strategy was developed to quantify methionine oxidation in an unstressed human proteome. Cell extracts were oxidized with 18O labelled hydrogen peroxide following cell lysis in order to convert all unoxidized methionine residues to an oxidized version with a heavy l...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD014629 | Pride
Methionine oxidation Unstressed proteome Human cell line 
ProteomicsIn vivo proteome of Pseudomonas aeruginosa in airways of cystic fibrosis patients
Chronic airway infection with P. aeruginosa (PA) is a hallmark of cystic fibrosis (CF) disease. The mechanisms producing PA persistence in CF therapies remain poorly understood. To gain insight on PA physiology in patient airways and better understand how in vivo bacterial functioning differs from...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa 
2019-05-09 | PXD011792 | Pride
Cystic fibrosis Bacterial population proteomes Pseudomonas aeruginosa Quantitative proteomics 
GenomicsEarly transcriptome and proteome changes in an in vivo model of post-traumatic osteoarthritis
Early transcriptome and proteome changes in an in vivo model of post-traumatic osteoarthritis
PRJEB8085 | ENA
UnknownTimepoint Selection Strategy for In Vivo Proteome Dynamics from Heavy Water Metabolic Labeling and LC-MS.
Not available
S-EPMC8864836 | biostudies-literature
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