Microarray data from muscle biopsy specimens from subjects with inclusion body myositis, polymyositis, and normals Experiment Overall Design: Microarray experiments
We investigated the gene and exon espression profiling in muscle biopsies of patients affected by inclusion body myosistis, polymyositis and in normal muscle controls
Inclusion body myositis (IBM) is a progressive muscle disease characterized by protein accumulation and anti-cN1A autoantibodies. This study aimed to identify post-translational modifications (PTMs) of cN1A in human skeletal muscle to understand its pathophysiological role. Using immunoaffinity puri...
HIBM is a neuromuscular disorder characterized by adult-onset, slowly progressive distal and proximal muscle weakness. Here, gene expression was measured in muscle specimens from 10 HIBM patients carrying the M712T Persian Jewish founder mutation in GNE and presenting with mild histological changes,...
Polymyositis with mitochondrial pathology (PM-Mito) was first identified in 1997 as a subtype of idiopathic inflammatory myopathy (IIM). Significant molecular similarities have been recently detected between PM-Mito and Inclusion Body Myositis (IBM), suggesting a trajectory from early to full-blown ...
