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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
TranscriptomicsTranscription profiling of human endothelial cells treated with Plasmodium falciparum-infected erythrocytes and/or TNF-alpha
Sensitisation of endothelium to TNFalpha induced by cytoadherence of Plasmodium falciparum infected red blood cells
ORGANISM(S): Homo sapiens 
2007-06-05 | E-SGRP-3 | biostudies-arrayexpress
ModelsKinetic model for infected red blood cell cultures (dutoit3)
Kinetic model for infected red blood cell cultures (dutoit3)
2023-10-14 | 841 | FAIRDOMHub
ProteomicsTurboID Proximity Profiling of FIKK10.2 (PF3D7_1039000) in Plasmodium falciparum–Infected Red Blood Cells During Febrile Heat Stress
This project investigates how febrile heat stress alters the local protein environment of the Maurer’s cleft resident kinase FIKK10.2 in the malaria parasite Plasmodium falciparum. During human infection, parasites are routinely exposed to elevated temperatures associated with fever, yet how this ph...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2026-05-14 | PXD073890 | Pride
Proximity labelling Heat stress Turboid Plasmodium falciparum 
ProteomicsCircadian Control of the Response of Macrophages to Plasmodium spp.-Infected Red Blood Cells.
In this study, we sought to determine whether the intensity of the immune response to Plasmodium spp., the parasite causing malaria, depends on time of infection. For this, we considered the known existence of a circadian clock in immune cells which regulates several aspects of the immune response. ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-26 | PXD049209 | Pride
Immune responses. Circadian rhythms Infected red blood cells Macrophages Plasmodium spp. 
TranscriptomicsInflammatory and immune responses in lymph nodes of Iberian red deer infected with Mycobacterium bovis.
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (Mycobacterium tuberculosis complex), is a zoonotic disease that affects cattle and wildlife worldwide. In some regions of Spain, Iberian red deer (Cervus elaphus hispanicus) can serve as reservoir of infection, thus increasing the risk of hum...
ORGANISM(S): Cervus elaphus hispanicus 
2007-10-17 | E-GEOD-6083 | biostudies-arrayexpress
TranscriptomicsComparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)
This SuperSeries is composed of the following subset Series: GSE33837: Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1) [miRNA] GSE33877: Comparative Expression Profile of miRNA and mRNA in Primary Perip...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33879 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of a 3D blood-brain-barrier model perfused with P. falciparum-infected red blood cells and egress products
This dataset consists of two individual sample-multiplexing (MULTI-seq) single-cell RNA sequencing experiments, MB10x01 and MB10x02. Single-cell RNA sequencing (10X Genomics) analyses were performed on a microfluidic 3D in vitro blood-brain-barrier model (containing primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2025-06-25 | E-MTAB-14463 | biostudies-arrayexpress
ProteomicsHigh mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria
In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans, expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD20...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD024022 | Pride
Red blood cells Sickle cells Malaria 
TranscriptomicsComparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1) [miRNA]
Host cells respond to exogenous infectious agents such as viruses, including HIV-1. Studies have evaluated the changes associated with virus infection at the transcriptional and translational levels of the cellular genes involved in specific pathways. While this approach is useful, in our view it pr...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33837 | biostudies-arrayexpress
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