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ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD063767 | Pride
Snps Allele-specific proteomics Allelic imbalance Mrna translation Eif4h 
ProteomicsAllele-resolved monosome and polysome sequencing identifies functional cis-acting variants affecting mRNA translation efficiency
To prioritize germline genetic variants affecting mRNA fate at the post-transcriptional and translational levels, we leveraged sucrose-gradient-based isolation of 80S monosomes and polysomes, followed by mRNA retrieval and paired-end sequencing. Total cytoplasmic RNA was also sequenced for compariso...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD078075 | Pride
80s monosome  polysome-profiling  translation efficiency  rna-sequencing  allele-specific mrna regulation 
TranscriptomicsTranscriptome and translatome profiling of MCF7 vector cells after p53 activation
Several genome-wide transcriptome analyses that focused on p53-induced cellular responses in many cellular contexts have continued to expand the already vast p53-regulated transcriptional networks. To investigate post-transcriptional controls as an additional dimension of p53-directed gene expressio...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-50650 | biostudies-arrayexpress
TranscriptomicsCrossroads of the p53, ER, NFkB stress response networks
We explored the combinatorial interactions between p53, estrogen receptors and NFkB using the breast adenocarcinoma-derived MCF7 cells. Recently, we have established that p53 can modulate transcription also through non-canonical response elements (REs), consisting of half-sites and ¾ sites. In parti...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24065 | biostudies-arrayexpress
ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo Sapiens 
PXD073180 | panorama
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