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ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD063767 | Pride
Snps Allele-specific proteomics Allelic imbalance Mrna translation Eif4h 
UnknownKey contribution of eIF4H-mediated translational control in tumor promotion.
Not available
S-EPMC4741870 | biostudies-literature
UnknownHerpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H.
Not available
S-EPMC387725 | biostudies-literature
UnknownThe eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase.
Not available
S-EPMC3401463 | biostudies-literature
UnknownCytoskeletal protein KRT14 governs cisplatin resistance by modulating eIF4H-dependent ACOX2 translation and lipid metabolism in bladder cancer.
Not available
S-EPMC12847778 | biostudies-literature
UnknowneIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.
Not available
S-EPMC6485101 | biostudies-literature
UnknownA bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus.
Not available
S-EPMC6070287 | biostudies-literature
ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo Sapiens 
PXD073180 | panorama
ProteomicsProximity labeling-based proteomic analysis of the HEV ORF1-associated replication complex under EIF4H deficiency
This project explores the role of EIF4H in regulating the composition of the HEV ORF1-associated replication complex using proximity-dependent biotin labeling with TurboID. TurboID was inserted into a validated permissive site within the ORF1 coding region that allows insertion without disrupting OR...
ORGANISM(S): Homo Sapiens 
PXD069279 |
TranscriptomicsEIF4A1 is essential in B cells by promoting activation-induced translation
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5’ untranslated regions but very little is known of their roles in non-malignant cells. Using mouse models to delete ...
ORGANISM(S): Mus musculus 
2023-07-21 | GSE237426 | GEO
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