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TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
TranscriptomicsRibosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity of Mammalian Proteomes
The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. Here we present a suite of techniques, based on ribosome profiling (the deep-sequencing of ribosome-protected mRNA fragments), to provide genome-wide maps of protein synthesis as well as a p...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-30839 | biostudies-arrayexpress
TranscriptomicsStage-specific regulation of translation revealed by ribosome profiling of Trypanosoma brucei
Trypanosoma brucei subspecies infect humans and animals in sub-Saharan Africa. This early diverging eukaryote shows many novel features in basic biological processes, including the use of polycistronic transcription to generate all protein-coding mRNAs. Therefore we hypothesized that translational...
ORGANISM(S): Trypanosoma brucei 
2014-05-24 | E-GEOD-57336 | biostudies-arrayexpress
TranscriptomicsIntegrative AUF1 PAR-CLIP analysis uncovers AUF1 roles in translation and genome integrity (PAR-CLIP)
We report that AUF1 modulates global mRNA stability and translation, in turn promoting the maintenance of DNA integrity. Please see individual series. In short, for AUF1 PAR-CLIP, the four isoforms of AUF1 (p37, p40, p42, and p45) tagged with a Flag epitope were expressed in HEK293 cells. For total ...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-52971 | biostudies-arrayexpress
ProteomicsR.norvegicus - Liver, SC (Orietal,cellsyst2015)
abundance based on Spectral counting, Interaction consistency score: 14.6, Coverage: 14
ORGANISM(S): 10116 
2015-00-00 | 3089243329 | PAXDB
ProteomicsR.norvegicus - Brain, SC (Orietal,cellsyst2015)
abundance based on Spectral counting, Interaction consistency score: 9.8, Coverage: 16
ORGANISM(S): 10116 
2015-00-00 | 860274101 | PAXDB
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