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MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
MetabolomicsLipolysis-derived Lipids Determine Autophagy Initiation during Fasting
Not available
ORGANISM(S): Caenorhabditis elegans 
ST002206 | MetabolomicsWorkbench
TranscriptomicsDeep sequencing reveals mRNA recruitment in translation initiation
We studied the initiation signals located in the translational initiation region (TIR) and identified the role for recognition of the initiation signals in each individual stage during formation of the initiation complexes. Sequencing the randomized mRNA libraries captured by translation initiation ...
ORGANISM(S): Escherichia coli 
2016-07-27 | E-GEOD-69782 | biostudies-arrayexpress
MetabolomicsPlasma Metabolome Normalization in Rheumatoid Arthritis following initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy
Not available
ORGANISM(S): Homo sapiens 
ST001949 | MetabolomicsWorkbench
ModelsSeptation Initiation Network
The Septation Initiation Network (SIN) controls cytokinesis in fission yeast. This model uses CDK activity levels as control nodes to simutate SIN related events throughout different stages of the cell cycle. This model was optimized using single knock-out experiments and has made in silico predicti...
4705 | Cell Collective
TranscriptomicsTranscription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells
Genomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory complexity of our genome. Here we combine a genome-wide approach to identify preferential sites of DNA replication initiation at 0.4% of the mouse genome with detailed molecular an...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-15082 | biostudies-arrayexpress
ProteomicsStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex, and the Regulation of Transcription
MedPIC: Crosslinking-MS of 54 subunit pre-initiation complex from yeast. MedPolII: Crosslinking-MS of 33 subunit Mediator + polII complex from yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2016-08-02 | MSV000080013 | MassIVE
ProteomicsProteomic Profiling Assessed by Data-Independent Acquisition Mass Spectrometry Revealed Enrichment in Myofibrillogenesis in the Heart Primordium after Heartbeat Initiation in Rats.
We investigated proteomic profiling assessed by data-independent acquisition mass spectrometry (DIA-MS) in the rat heart primordia before and after heartbeat initiation at embryonic day 10.0, when heartbeat begins in rats, and in the primordial heart tube at embryonic day 11.0.
ORGANISM(S): Rattus Rattus (black Rat) 
2022-06-02 | PXD032987 | JPOST Repository
GenomicsOrchestration of Floral Initiation by APETALA1
The MADS-domain transcription factor APETALA1 (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding s...
ORGANISM(S): Arabidopsis thaliana 
2010-04-02 | E-GEOD-20176 | biostudies-arrayexpress
TranscriptomicsGlucose depletion inhibits translation initiation in yeast - transcription profiling
This is a transcription profiling study on yeast undergoing glucose depletion. It reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss and 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-11 | E-MEXP-3037 | biostudies-arrayexpress
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