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MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
TranscriptomicsOtitis Media Impact on Inner Ear
Objective: Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken. Ninety-nine percent of mouse genes are shared in the human, so these stu...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-49122 | biostudies-arrayexpress
TranscriptomicsInner ear expression data from pooled inner ear tissue from stages 56,57,58 Xenopus laevis larval inner ears
The inner ear continues to grow and develop until the auditory and vestibular systems reach full maturity and all of the genes involved in this process have yet to be identified. Previous gene based analysis have primarily focused on the early developmental stages following induction and initial for...
ORGANISM(S): Xenopus laevis 
2016-02-29 | E-GEOD-73829 | biostudies-arrayexpress
TranscriptomicsOtitis Media Impact on Middle Ear
Objective: Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken. Ninety-nine percent of mouse genes are shared in the human, so these stu...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-49128 | biostudies-arrayexpress
ProteomicsInner ear hair cell proteome
The mammalian inner ear subserves auditory and vestibular sensations via highly specialized cells and proteins. We show that sensory hair cells (HCs) employ hundreds of uniquely or highly expressed proteins for processes involved in transducing mechanical inputs, stimulating sensory neurons, and mai...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-23 | MSV000079756 | MassIVE
TranscriptomicsTranscription profiling of mouse discrete microdissected inner ear tissues from E9 to E15 at half-day intervals.
The inner ear in mammals is derived from a simple ectodermal thickening called the otic placode. Through a series of complex morphological changes, the placode forms the mature inner ear comprising of the auditory organ (cochlea) and the vestibular/balance organs (utricle, saccule, and three semi-ci...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7536 | biostudies-arrayexpress
TranscriptomicsWild-type and COUP-TFI-/- newborn inner ear microarrays
In order to establish a list of candidate direct COUP-TFI gene targets in the inner ear, we analyzed the differential gene expression profiles of the wild-type and the COUP-TFI–/– P0 inner ears. We performed a total of 8 microarray experiments using Affymetrix MG-U74Av2 chips, including 2 biol...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-16744 | biostudies-arrayexpress
TranscriptomicsRNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM® genes for hereditary disorders of hearing and balance
Purpose: To identify orthologous genes in Xenopus that are implicated in deafness and vestibular disorders in humans and to compare RNA-Seq and microarray to determine the advantages of each technology for Xenopus transcriptomic analysis. Methods: Inner ear RNA from X. laevis stages 56-58 was isolat...
ORGANISM(S): Xenopus laevis 
2016-02-28 | E-GEOD-69701 | biostudies-arrayexpress
TranscriptomicsIdentification of microRNA targets in the mammalian inner ear using a comprehensive transcriptome and proteome integrated approach
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions using integrated miRNA, transcriptome and proteome profiles with advanced in silico analysis. By looking at both the transcript and protein levels of expression, a thorough coverag...
ORGANISM(S): Mus musculus 
2011-04-20 | E-GEOD-23081 | biostudies-arrayexpress
ProteomicsInner ear exosomes and their potential use as biomarkers
Exosomes are nanovesicles involved in intercellular communications. They are released by a variety of cell types; however, their presence in the inner ear has not been described in the literature. The aims of this study were to determine if exosomes are present in the inner ear and, if present, char...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-07-04 | PXD009483 | Pride
Exosome Inner ear Label-free quantification 
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