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ProteomicsINPP5D regulates inflammasome activation in human microglia
Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D) is a myeloid-expressed gene genetically-associated with AD. Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046040 | Pride
Lc-ms/ms Alzheimer's Inpp5d 
GenomicsINPP5D/SHIP1 regulates inflammasome activation in human microglia
INPP5D/SHIP1 regulates inflammasome activation in human microglia
PRJNA1021661 | ENA
GenomicsLoss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes
Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes
PRJNA1072999 | ENA
GenomicsINPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
PRJNA723566 | ENA
UnknownINPP5D regulates inflammasome activation in human microglia.
Not available
S-EPMC10684891 | biostudies-literature
TranscriptomicsINPP5D/SHIP1 regulates inflammasome activation in human microglia
Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). To better understand microglia-mediated processes in AD, we studied the function of INPP5D/SHIP1, a gene linked to AD through GWAS. Immunostaining and single nucleus RNA sequencing confirme...
ORGANISM(S): Homo sapiens 
2023-09-27 | GSE244209 | GEO
UnknownInpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy.
Not available
S-EPMC11247686 | biostudies-literature
UnknownLoss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes.
Not available
S-EPMC11350029 | biostudies-literature
TranscriptomicsLoss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes
INTRODUCTION: INPP5D is genetically associated with Alzheimer’s disease risk. Loss of Inpp5d alters amyloid pathology in models of amyloidosis. Inpp5d is predominantly expressed in microglia but its function in brain is poorly understood. METHODS: We performed single-cell RNA-sequencing to study the...
ORGANISM(S): Mus musculus 
2024-06-26 | GSE254999 | GEO
TranscriptomicsINPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
We crossed Tyrobp-deficient and Inpp5d-deficient mice with App(NL-G-F/NL-G-F) Alzheimer model mice (hereafter, NLGF) and generate Tyrobp-/-;Inpp5d+/-;NLGF mice to assess the role of Inpp5d in Tyrobp-/- mice. We isolated microglia from NLGF, Tyrobp-/-;NLGF, and Tyrobp-/-;Inpp5d+/-;NLGF mice and analy...
ORGANISM(S): Mus musculus 
2023-02-24 | GSE172499 | GEO
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