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MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
ProteomicsProteomic profiles of INS1 cells
In this study, we obtained proteomic profiles of INS1 cells with lipotoxicity and glucolipotoxicity in a time-course fashion.
ORGANISM(S): Rattus rattus (Black rat) 
2018-08-14 | PXD008154 | Pride
Ins1 lipotoxicity glucolipotoxicity 
GenomicsThermaerobacter composti strain:Ins1
Thermaerobacter composti strain:Ins1 Genome sequencing
PRJNA999239 | ENA
TranscriptomicsRNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets
The CCR4-NOT dedadenylase complex is essential for mRNA decay and various biological events.To understand roles of the complex in pancreatic beta cells, we compared global gene expression in Ins1-cre driven Cnot3 KO and control islets. Cnot3 is an important subunit of the complex and its knockout af...
ORGANISM(S): Mus musculus 
2020-08-29 | E-MTAB-8729 | biostudies-arrayexpress
ProteomicsProteomics via immune-precipitation assisted Mass-Spectrometry of Androgen receptor in INS1 cells.
IP- Mass Spec of INS1 cells treated with DHT or GLP1 and then subjected to IP of AR protein and subsequent mass spec to identify binding partners of AR relevant to Insulin signaling and secretion.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-17 | PXD041592 | Pride
Ins1 Androgen receptor Insulin signaling Beta cell biology 
TranscriptomicsINS1 cells expressing either WT IRE1α, I642G IRE1α, N906A IRE1α, or spliced XBP1 treated with dox and 1NMPP1
Transcriptional profiling of INS1 cells expressing either WT IRE1α, I642G IRE1α, N906A IRE1α, or spliced XBP1 comparing 1μg/mL dox and 5μM 1NMPP1 treated vs control. All arrays are hybed pairwise with treated hybed against untreated
ORGANISM(S): Rattus norvegicus 
2014-12-22 | E-GEOD-17148 | biostudies-arrayexpress
TranscriptomicsINS1 CAT cells treated with 1μM thapsigargin vs control.
Transcriptional profiling of INS1 CAT cells treated with 1μM thapsigargin vs control.
ORGANISM(S): Rattus norvegicus Mus musculus 
2014-12-22 | GSE17150 | GEO
ProteomicsMANF interactomes by AP-MS method in two mammalian cell lines, the HEK293 and INS1
AP-MS approach to identify MANF-interacting proteins from HEK293 and INS1 cell lines. Proteins were identified and MS1 quantified using Andromeda search engine and MaxQuant proteomics software 92. Thermo .raw files were searched against the human or rat component of the UniProt-database complemented...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) 
2020-10-21 | MSV000086342 | MassIVE
GenomicsRNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets
RNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets
PRJEB36397 | ENA
UnknownAAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects.
Not available
S-EPMC7324556 | biostudies-literature
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