Insulin transcription

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Unknown (3064)
Transcriptomics (2383)
Genomics (851)
Proteomics (63)
Metabolomics (19)
Other (12)
Methylation profiling (6)
Models (4)

Organisms

Homo sapiens (1102)
Mus musculus (1039)
Rattus norvegicus (209)
Drosophila melanogaster (95)
Caenorhabditis elegans (83)
Sus scrofa (20)
Bos taurus (19)
Arabidopsis thaliana (16)
Saccharomyces cerevisiae (8)
synthetic construct (7)
Danio rerio (6)
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Schizosaccharomyces pombe (3)
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Rattus (1)

Organisms

Mus musculus (239)
Homo sapiens (164)
Caenorhabditis elegans (33)
Rattus norvegicus (32)
Drosophila melanogaster (26)
Bos taurus (6)
Sus scrofa (5)
Sparus aurata (3)
Cyprinus carpio (2)
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Gerromorpha (1)
Tribolium castaneum (1)
Macaca fascicularis (1)
Oreochromis niloticus (1)
Gallus gallus gallus (1)
Oncorhynchus mykiss (1)
Equus caballus (1)
Pimephales promelas (1)
Saccharomyces cerevisiae (1)

Repository

biostudies-arrayexpress (2145)
ENA (581)
geo (487)
EGA (46)
pride (42)
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PanoramaPublic (1)

Tissue

Cell culture (9)
Adipose tissue (3)
Beta-TC3 cell (2)
Alpha-TC1.6 cell (2)
Pancreatic islet cell (2)
Blood (2)
Permanent cell line cell (2)
Stem cell (2)
Kidney (2)
Whole body (2)
Liver (2)
Hepatocyte (2)
Regulation of endothelial cell differentiation (1)
Fat cell differentiation (1)
Pancreatic beta cell line (1)
Pancreatic alpha cell (1)
Fat cell (1)
Myoblast (1)
Type B pancreatic cell (1)
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Disease

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Neuroendocrine tumor (1)
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Insulitis and diabetes (1)
HIV-associated dementia (1)
Metabolic syndrome (1)
Aggressive insulitis (1)
Nondiabetic (1)
Adenoma (1)
Replicate control (1)
Model of metabolic syndrome (1)
Chondroblastoma (1)
Insulin resistance (1)
Glioma (1)
Controled disease patient (1)
Basal cell carcinoma, Gorlin-Goltz syndrome (1)
Primary tumor (1)
Liposarcoma (1)
Type 1 Diabetes Mellitus (1)
Sham surgery (1)
Invasive lobular carcinoma (1)
Disease controled patient (1)
Hyperglycaemic (1)
Colon cancer (1)

Technology Type

Mass Spectrometry (42)
Shotgun proteomics (18)
Mass spectrometry (14)
Bottom-up proteomics (13)
Affinity purification coupled with mass spectrometry proteomics (6)
Data-dependent acquisition (5)
Mass spectrometry assay (4)
Data-independent acquisition (4)
Top-down proteomics (3)
ILLUMINA, Illumina HiSeq 2500 (2)
All-ion fragmentation (2)
ILLUMINA, Illumina Genome Analyzer IIx, Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, Illumina_2.5M (1)
Affinity proteomics (1)
Gel-based experiment (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (57)
Illumina HiSeq 2500 (54)
Illumina HiSeq 2000 (45)
NextSeq 500 (42)
Illumina HiSeq 4000 (16)
Affymetrix Fluidics Station 400 (9)
Illumina NovaSeq X (8)
NextSeq 2000 (5)
DNBSEQ-G400 (4)
NextSeq 550 (4)
Illumina Genome Analyzer IIx (3)
Illumina (3)
Controlled-environment growth chamber (short-day; 8 h light / 16 h dark) (2)
Microcentrifuge (2)
Agilent DNA Microarray Scanner Model #G2565BA (2)
Linux computer (2)
Illumina Genome Analyzer (2)
G2500A GeneArray scanner [Agilent Technologies] (2)
ScanArray Express HT [PerkinElmer] (2)
ScanArray Express HT (2)
Axon GenePix 4000B scanning hardware (2)
NA (2)
Agilent NGS Workstation (2)
ACCRE (2)
HiSeq X Ten (2)
Illumina HiSeq 1500 (2)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Cell culture (1)
ProFlex PCR system (1)

Publication Date

2013 (272)
2010 (248)
2015 (243)
2014 (213)
2012 (201)
2008 (201)
2011 (187)
2016 (159)
2009 (158)
2007 (132)
2026 (111)
2023 (74)
2025 (73)
2024 (62)
2021 (59)
2022 (57)
2019 (53)
2020 (51)
2018 (51)
2006 (46)
2017 (42)
2005 (14)
2004 (8)
2003 (4)
2027 (1)

UNIPROT ID/AC

Q10586 (1)
P20393 (1)
Q9QY78 (1)
A9LRT4 (1)
P21581 (1)
Q4VSI4 (1)
Q62671 (1)
Q99MA1 (1)
Q09137 (1)
Q63699 (1)
Q06226 (1)
O09139 (1)
P07895 (1)
O54857 (1)
P19357 (1)
O60343 (1)
O88763 (1)
P20417 (1)
P15127 (1)
P01322 (1)
G3V7R4 (1)
P42346 (1)
P35570 (1)
P47196 (1)
Q64623 (1)
O14920 (1)
P16278 (1)
P45983 (1)
Q6I9V6 (1)
P38936 (1)

CHEBI ID

CHEBI:16856 (5)
CHEBI:17927 (4)
CHEBI:9410 (3)
CHEBI:17858 (2)
CHEBI:16991 (2)
CHEBI:26523 (2)
CHEBI:37328 (1)
CHEBI:60169 (1)
CHEBI:4705 (1)
CHEBI:33697 (1)
CHEBI:16874 (1)
CHEBI:30633 (1)
CHEBI:16565 (1)
CHEBI:9533 (1)
CHEBI:36528 (1)
CHEBI:15958 (1)
CHEBI:28101 (1)
CHEBI:7101 (1)
CHEBI:16480 (1)
CHEBI:36259 (1)
CHEBI:17969 (1)
CHEBI:28743 (1)
CHEBI:28865 (1)
CHEBI:35420 (1)
CHEBI:4250 (1)
CHEBI:16382 (1)
CHEBI:18318 (1)
CHEBI:37998 (1)
CHEBI:17687 (1)
CHEBI:16066 (1)

Metabolite Name

Stearic acid (3)
Glucose (3)
Butoctamide hydrogen succinate (2)
Oblongolide (2)
Arginyl-Glutamine (2)
Sn-3-O-(geranylgeranyl)glycerol 1-phosphate (2)
Succinylproline (2)
17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid (2)
1-(1,2,3,4,5-Pentahydroxypent-1-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate (2)
3-Indoleacetic Acid (2)
THTC (2)
Aminohydroquinone (2)
D-erythro-Sphingosine C-15 (2)
PE(16:0/0:0) (2)
Succinoadenosine (2)
(4E,8E,10E-d18:3)sphingosine (2)
(6S)-dehydrovomifoliol (2)
Metaxalone (2)
Isovalerylglutamic acid (2)
Isoleucyl-Hydroxyproline (2)
Remikiren (2)
Palmitoleamide (2)
N-Nitrosoguvacoline (2)
1-Methylguanosine (2)
Hydroxyprolyl-Leucine (2)
Serine (2)
26-Glucosyl-1,3,11,22-tetrahydroxyergosta-5,24-dien-26-oate (2)
D-Urobilinogen (2)
L-Methionine S-oxide (2)
Melleolide (2)

IsPrivate

False (4)

First Public Date

2014 (135)
2026 (70)
2023 (49)
2025 (48)
2024 (43)
2021 (36)
2015 (35)
2019 (34)
2020 (33)
2022 (27)
2018 (23)
2017 (22)
2016 (16)
2013 (10)

Modelling Approach

Ordinary differential equation model (4)

Study type

Transcription profiling by array (1462)
RNA-seq of coding RNA (298)
ChIP-seq (140)
RNA-seq of coding RNA from single cells (45)
Unknown experiment type (25)
RNA-seq of non coding RNA (22)
ChIP-chip by tiling array (18)
Methylation profiling by array (18)
Other (16)
RNA-seq of total RNA (16)
RNAi profiling by array (7)
ChIP-chip by array (7)
Comparative genomic hybridization by array (7)
Methylation profiling by high throughput sequencing (7)
MicroRNA profiling by array (5)
Cell line - High-throughput sequencing (4)
Genotyping by array (4)
Human - Single-cell sequencing (3)
Transcription profiling by RT-PCR (3)
DNA-seq (3)
Cell line - Single-cell sequencing (2)
Baseline (2)
Differential (2)
Animal - One-color microarray (2)
Animal - High-throughput sequencing (2)
MicroRNA profiling by high throughput sequencing (2)
CUT&RUN (2)
RAN-seq of total RNA from single cells (1)
Transcription profiling by SAGE (1)
CLIP-Seq (1)

Release Date

2013 (375)
2015 (350)
2014 (341)
2016 (319)
2010 (318)
2012 (296)
2022 (283)
2011 (282)
2021 (264)
2008 (261)
2020 (256)
2023 (249)
2009 (232)
2018 (230)
2019 (219)
2025 (212)
2017 (192)
2024 (167)
2007 (163)
2006 (63)
2026 (45)
2005 (33)
2004 (19)
2003 (16)
2002 (5)
2000 (4)
1997 (4)
2001 (3)
1999 (3)
1998 (3)

Lab affiliation

Kubicek lab, Principal Investigator, Head of Molecular Discovery Platform, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (3)
Novo Nordisk Foundation Center for Biosustainability (2)
Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore (1)
Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3C584 CG Utrecht, The Netherlands (1)
Division of Food and Bioscience College of Biomedical and Health Science Konkuk University Glocal Campus, Republic of Korea (1)
State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China (1)
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Japan (1)
Cell Signaling and Immunology School of Life Sciences University of Dundee (1)
Faculty of Science, Charles University, 12800 Prague, Czech Republic (1)
Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy. Department of Medical and Translational Science, University of Naples "Federico II", Italy. (1)
Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy Department of Translational Medicine, Federico II University , Naples , Italy (1)
Smilow Center for Translational Research 12-124 3400 Civic Center Blvd Philadelphia, PA 19104 P: 215-573-5413 F: 215-898-5408 (1)
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany (1)
Division of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, and Heart and Vascular Center, University of Iowa, University of Iowa, Iowa City, Iowa, USA. (1)
Proteomics Core Facility, Biozentrum, University of Basel, Spitalstrasse 41, CH-4056 Basel / Switzerland, Phone: +41 61 207 20 59, email: alex.schmidt@unibas.ch (1)
Cell Biology and Disease Mechanisms, TeleThon Institute of Genetics and Medicine (1)
Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany; School of Medicine, Technical University of Munich, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany. (1)
Max-Planck Institute of Biochemistry (1)
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center Harvard Medical School Broad Institute of Harvard and MIT (1)
Department of Gene Expression Institute of Molecular Biology and Biotechnology Faculty of Biology Adam Mickiewicz University Poland (1)
Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany. and German Center for Diabetes Research (DZD), Neuherberg, Germany;d German Center for Diabetes Research, Neuherberg, Germany (1)
Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine (1)
Harvard School of Public Health (1)
Medizinisches Proteom-Center (1)
Proteomics Platform Necker, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris 75015, France. (1)
Boston University (1)
Institute of Aquaculture, University of Stirling (1)
Institute of Science and Technology Austria (ISTA) (1)
Energy Metabolism Laboratory, Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zurich, Schwerzenbach, CH-8603, Switzerland (1)
Professor of Renal Medicine, Bristol Medical School, Bristol Royal hospital for Sick Children & University of Bristol (1)

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Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...

2018-04-26 | MTBLS582 | MetaboLights

Comprehensive analysis of different in vitro insulin resistance models

Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. W...

ORGANISM(S): Mus musculus

2013-10-18 | E-GEOD-35724 | biostudies-arrayexpress

Function-based discovery of significant transcriptional temporal patterns in insulin-stimulated muscle cells

Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcri...

ORGANISM(S): Rattus norvegicus

2012-05-02 | E-GEOD-28997 | biostudies-arrayexpress

Transcription and translation profiling of rat cardiomyocytes treated with insulin

Effect of insulin on the cardiomyocyte global transcriptome and RNAs recruited to polysomes.
For comparison with endothelin-1

ORGANISM(S): Rattus norvegicus

2010-07-04 | E-MEXP-2527 | biostudies-arrayexpress

Transcriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin

The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...

ORGANISM(S): Homo sapiens

2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress

Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?

Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...

ORGANISM(S): Rattus norvegicus

2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress

Human Insulin Resistance and Thiazolidinedione-Mediated Insulin Sensitization

Cellular and tissue defects associated with insulin resistance are coincident with transcriptional abnormalities and are improved after insulin sensitization with thiazolidinedione (TZD) PPAR? ligands. We transcriptionally profiled 364 biopsies gathered from 72 human subjects harvested before and af...

ORGANISM(S): Homo sapiens

2010-05-17 | E-GEOD-13070 | biostudies-arrayexpress

Transcription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin

Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...

ORGANISM(S): Mus musculus

2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress

Real-time quantitative PCR analysis of human colonic HT-29 cells under insulin stimulation

Compared mRNA expression between control and insulin treated cells. HT29 cells were treated with 100nM Insulin for 24h. The RT2 Profiler PCR Arrays PAHS-30C (SA Biosciences, MD, USA) was designed to analyze 84 genes related to human insulin signaling pathway. The RT-PCR was carried out using an ABI ...

ORGANISM(S): Homo sapiens

2014-06-01 | E-GEOD-51677 | biostudies-arrayexpress

Transcription profiling of brown adipose tissue in a glycerol kinase (Gyk) knockout mouse model to define GyKs role in insulin resistance

Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been implicated in insulin resistance and type 2 diabetes mellitus (T2DM). To define GK's role in insulin resistance, we examined gene expression in brown adipose tissue in a glycerol kinase (Gyk) knockout (KO) mouse...

ORGANISM(S): Mus musculus

2007-11-22 | E-GEOD-4656 | biostudies-arrayexpress

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6414 Results

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