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ProteomicscircTBRII(3-6) acts as assembly platform for IGF2BP3 protein and TBRI mRNA to enhance breast cancer cell plasticity
Transforming growth factor (TGF)-β signaling is a key driver to induce epithelial-to-mesenchymal transition (EMT), a process that enhances cancer cell plasticity and metastatic potential. However, the role of circular RNAs (circRNAs) in TGF-β signaling remains largely unexplored. Here, we identify c...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061218 | Pride
Insulin-like growth factor 2 mrna binding protein 3 Circtbrii(3-6) Epithelial-to-mesenchymal transition Transforming growth factor (tgf)-β 
TranscriptomicsTranscription profiling of C. elegans lin-14 mutants
A temporal gradient of the novel nuclear protein LIN-14 specifies the timing and sequence of stage-specific developmental events in Caenorhabditis elegans. The profound effects of lin-14 mutations on worm development suggest that LIN-14 directly or indirectly regulates stage-specific gene expression...
ORGANISM(S): Caenorhabditis elegans 
2007-01-05 | E-SMDB-3919 | biostudies-arrayexpress
TranscriptomicsCarcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications
We here show that loss of imprinting (LOI) of IGF2 is a frequent and early event in the development of colon cancer and occurs throughout the large intestine. LOI leads to AKT1-dependent activation and suppression of a defined set of genes, many of which are cell cycle related. Our results further s...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-66726 | biostudies-arrayexpress
GenomicsInsulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis
Insulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis
PRJNA633384 | ENA
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
ProteomicsThe interactome of Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds various RNA transcripts and functions as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism (1-3). Here we find that IGF2BP2 binds to the 3’ untranslated region of the tran...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028084 | Pride
Sirt1 Igf2bp2 Protein-protein interactions 
TranscriptomicsExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Although estrogen receptor (ER) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer, cross-talk between these pathways, particularly at the level of gene transcription, remains poorly understood. We performed microarray analysis on MCF-7 bre...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-26834 | biostudies-arrayexpress
UnknownInsulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Not available
S-EPMC5706827 | biostudies-literature
UnknownInsulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability.
Not available
S-EPMC8810085 | biostudies-literature
UnknownCD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma.
Not available
S-EPMC7657237 | biostudies-literature
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