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ProteomicsThe interactome of Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds various RNA transcripts and functions as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism (1-3). Here we find that IGF2BP2 binds to the 3’ untranslated region of the tran...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028084 | Pride
Sirt1 Igf2bp2 Protein-protein interactions 
ProteomicsThe RNA Binding Protein IGF2BP2 is Upregulated by Stress in the Heart and Causes Mitochondrial Dysfunction and Dilated Cardiomyopathy
The IGF2BP family of RNA binding proteins consists of three paralogs, IGF2BP1, 2, and 3, that regulate RNA function at many levels, including intracellular RNA localization, RNA stability, and translational control. Although IGF2BP1 and 3 are oncofetal proteins, IGF2BP2 expression is maintained in m...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD037623 | Pride
Heart Mouse Lcms Igf2bp2 
ProteomicsProteomic analysis of SKOV3 cells expressing wild-type and mutant IGF2BP2-TurboID
Proteomic dataset identifying IGF2BP2-associated proteins in SKOV3 cells using a TurboID-based proximity labeling approach. Wild-type and mutant IGF2BP2-TurboID constructs were compared to elucidate the molecular mechanisms by which IGF2BP2 regulates mRNA translation.
ORGANISM(S): Homo sapiens (Human) 
2025-11-09 | PXD069360 | Pride
Turboid-based proximity labeling Ovrian cancer cell 
ProteomicsIgf2bp2 deletion reduces energy metabolism, gIgf2bp2 deletion reduces energy metabolism, growth signaling, and aging of hematopoietic stem cells in micerowth signaling, and aging of hematopoietic stem cells in mice
Increasing evidence links metabolic activity and cell growth to decline in hematopoietic stem cell (HSC) function during aging. The Lin28b/Hmga2 pathway controls tissue development and in the hematopoietic system the postnatal downregulation of this pathway causes a decrease in self renewal of adult...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD018535 | Pride
Mitochondrial metabolism Protein synthesis and mtor/pi3k-dependent differentiation of hematopoietic stem cells. Igf2bp2 drives glycolysis 
TranscriptomicsIMP2/IGF2BP2 HITS-CLIP from E13.5 mouse brain
HITS-CLIP is performed for the RNA-binding protein, IMP2/IGF2BP2, from E13.5 mouse brain.
ORGANISM(S): Mus musculus 
2016-06-06 | E-MTAB-3636 | biostudies-arrayexpress
GenomicsIMP2/IGF2BP2 HITS-CLIP from E13.5 mouse brain
IMP2/IGF2BP2 HITS-CLIP from E13.5 mouse brain
PRJEB9614 | ENA
ProteomicsThe RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
ORGANISM(S): Homo sapiens (Human) 
2024-10-11 | PXD052287 | Pride
Extracellular vesicles Igf2bp2 Human 
GenomicsIGF2BP2 promotes esophageal squamous cell carcinoma progression through the PI3K/AKT signaling pathway
IGF2BP2 promotes esophageal squamous cell carcinoma progression through the PI3K/AKT signaling pathway
PRJNA1481297 | ENA
GenomicsDynamics of m6A RNA methylome during leukemogenesis reveals a role of IGF2BP2-PRMT6-MFSD2A signaling axis in maintaining AML stem cells [IGF2BP2 RNA-seq]
Dynamics of m6A RNA methylome during leukemogenesis reveals a role of IGF2BP2-PRMT6-MFSD2A signaling axis in maintaining AML stem cells [IGF2BP2 RNA-seq]
PRJNA864888 | ENA
GenomicsInhibition of the m6A Reader IGF2BP2 as a Strategy against T-cell Acute Lymphoblastic Leukemia
Inhibition of the m6A Reader IGF2BP2 as a Strategy against T-cell Acute Lymphoblastic Leukemia
PRJNA846158 | ENA
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