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TranscriptomicsExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Although estrogen receptor (ER) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer, cross-talk between these pathways, particularly at the level of gene transcription, remains poorly understood. We performed microarray analysis on MCF-7 bre...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-26834 | biostudies-arrayexpress
GenomicsGene expression analysis of BeWo cells stimulated by tumor necrosis factor-alpha and insulin-like growth factor-I
Gene expression analysis of BeWo cells stimulated by tumor necrosis factor-alpha and insulin-like growth factor-I
PRJNA489858 | ENA
GenomicsDNA methylation analysis of BeWo cells stimulated by tumor necrosis factor-alpha and insulin-like growth factor-I
DNA methylation analysis of BeWo cells stimulated by tumor necrosis factor-alpha and insulin-like growth factor-I
PRJNA489857 | ENA
TranscriptomicsNeurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons; playing a role in the maintenance of the synaptic unions, dendrites and axons; also, being crucial for peripheral nervous system development and regulating pl...
ORGANISM(S): Mus musculus 
2018-12-29 | E-MTAB-7508 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human SK-N-AS neuroblastoma xenograft tumor treated with anti-human IGF-IR monoclonal antibody (h10H5) to study the anti-tumour function of the antibody
The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through type I IGF receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to malignant growth of many types of human cancers. We have developed a humanize...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary visual cortext from animals treated with monocular deprivation (MD), dark rearing and controls reveals binding protein of Insulin-like Growth Factor 1 is highly upregulated after MD
Two key paradigms for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD).,Combining DNA microarray analysis with computational appr...
ORGANISM(S): Mus musculus 
2007-07-07 | E-GEOD-4537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild_type and IGF-I receptor over-expressing mouse lung carcinoma cells identifies a type I insulin like growth factor receptor regulated gene expression profile associated with an altered site-specificity of metastasis.
Identification of a type I insulin like growth factor receptor regulated gene expression profile associated with an altered site-specificity of metastasis.
ORGANISM(S): Mus musculus 
2008-11-01 | E-MEXP-1361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse knock in mutant model for spinocerebellar ataxia type 1 and type 7 - symptomatic Sca1154Q/2Q and Sca7266Q/5Q cerebellum
Comparative analysis of cerebellar gene expression changes occurring in Sca1154Q/2Q and Sca7266Q/5Q knock-in mice; Polyglutamine diseases are inherited neurodegenerative disorders caused by expansion of CAG repeats encoding a glutamine tract in the disease-causing proteins. There are nine disorders...
ORGANISM(S): Mus musculus 
2009-01-09 | E-GEOD-9914 | biostudies-arrayexpress
TranscriptomicsPlatelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor
Platelets contain abundant miRNAs, however, the biogenesis pathway of miRNAs in anucleate platelets is unclear. Platelet-rich plasma was diluted in washing buffer and the platelet suspension was centrifuged to isolated pure platelets.Finally, platelets were recovered in suspension buffer at the conc...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-51453 | biostudies-arrayexpress
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
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