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MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
TranscriptomicsC-peptide regulates early transcription in rat proximal tubular cells
C-peptide exerts beneficial effects on glomerular hyperfiltration in type I diabetic patients. As C-peptide localizes to the nucleus, we investigated the transcriptional activities of C-peptide in proximal tubular cells isolated from diabetic rats. Two groups of proximal tubular cells isolated from ...
ORGANISM(S): Rattus norvegicus 
2011-07-26 | E-GEOD-24687 | biostudies-arrayexpress
ProteomicsDrosophila insulin-like peptides DILP2 and DILP5 stimulation global phosphoproteome
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including growth, development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated by eight Drosophila insulin-like peptides (DILPs), homologues of both mammalian insulin and IGFs, with ...
ORGANISM(S): Drosophila melanogaster Drosophila melanogaster (Fruit fly) 
2018-10-19 | PXD009240 | Pride
Insulin-like peptide Insulin/igf signaling Dilp Drosophila 
GenomicsA singular cockroach insulin-like peptide specific for a male reproductive gland
A singular cockroach insulin-like peptide specific for a male reproductive gland
PRJNA1242779 | ENA
TranscriptomicsCOUP-TFII Controls Mouse Postnatal Pancreatic β-Cell Mass through GLP-1 β-Catenin
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
2011-10-06 | E-GEOD-30526 | biostudies-arrayexpress
TranscriptomicsIPC knockout, 14 day old female flies, 48h yeast feeding
Background Insulin signaling pathway is conserved from worms to humans. In Drosophila, three insulin-like peptides (dilps) are expressed in the insulin producing cells (IPCs) in the brain. In order to identify target genes of insulin signaling, the IPCs of female flies were destroyed during develop...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-10625 | biostudies-arrayexpress
UnknownDiverse functions of insulin-like 3 peptide.
Not available
S-EPMC7453995 | biostudies-literature
UnknownvPIF-1 is an insulin-like antiferroptotic viral peptide.
Not available
S-EPMC10214148 | biostudies-literature
GenomicsThe Toll signaling pathway targets the insulin-like peptide Dilp6 to inhibit growth in Drosophila
The Toll signaling pathway targets the insulin-like peptide Dilp6 to inhibit growth in Drosophila
PRJNA552104 | ENA
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