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TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
ProteomicsScreening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists
Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization and use of a vertebrate 'insulin-free' model to identify insulin-independent modulators of glucose metabolism. insuli...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-12-13 | PXD012027 | Pride
Chemical screen Metabolism Insuline mutant Zebrafish Glucose homeostasis 
TranscriptomicsTranscription profiling of Drosophila Spargel mutant versus genetically matched wildtype control
Mammalian PGC-1alpha, PGC-1beta and PRC are structurally related transcriptional coactivators, and are involved in multiple metabolic functions, including the regulation of mitochondrial biogenesis. However, due to redundancy, their in vivo roles are still poorly understood. By a genome-wide microar...
ORGANISM(S): Drosophila melanogaster 
2009-02-21 | E-GEOD-14780 | biostudies-arrayexpress
TranscriptomicsGene expression data of brown-like adipocytes from Lgr4 homozygous mutant SVF
Obesity has become a global health problem. Brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Recently, BAT is also identified in human adults. We found that Lgr4 homozygous mutant (Lgr4m/m) mice display reduced adiposity and exhibit ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-47760 | biostudies-arrayexpress
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
TranscriptomicsExpression data from normal and MDS erythroids cell cutlures ex vivo
CD34 positive cells of bone marrow samples from normal and MDS samples were cultured ex vivo into erythroid conditions. We used microarrays to detail the gene expression programm of erythroid cells between normal and pathological (MDS) samples Mononuclear cells from bone marrow samples were selected...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-34268 | biostudies-arrayexpress
TranscriptomicsImpaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- kno...
ORGANISM(S): Caenorhabditis elegans 
2012-02-25 | E-GEOD-36041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Spargel mutants vs. controls to investigate the effect of Spargel on transcriptional changes mediated by the insulin-signalling pathway
Insulin signalling activity is well known to mediate transcriptional changes in response to nutrients and it is changed in the spargel mutant. We performed a genome-wide microarray study to investigate the role of Spargel as a transcriptional coregulator downstream of insulin receptor signalling. ...
ORGANISM(S): Drosophila melanogaster 
2009-02-26 | E-GEOD-14779 | biostudies-arrayexpress
TranscriptomicsExpression from C. elegans L1 animals
Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation. Whole genome transcrip...
ORGANISM(S): Caenorhabditis elegans 
2009-12-31 | E-GEOD-18130 | biostudies-arrayexpress
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