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ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
GenomicsThe CDK12-INTAC Axis Modulates LEO1 Phosphorylation for Processive Transcription Elongation
The CDK12-INTAC Axis Modulates LEO1 Phosphorylation for Processive Transcription Elongation
PRJNA899509 | ENA
GenomicsCatalytic-independent functions of INTAC confer sensitivity to BET inhibition [CUT&Tag]
Catalytic-independent functions of INTAC confer sensitivity to BET inhibition [CUT&Tag]
PRJNA1146476 | ENA
GenomicsCatalytic-independent functions of INTAC confer sensitivity to BET inhibition [RNA-seq]
Catalytic-independent functions of INTAC confer sensitivity to BET inhibition [RNA-seq]
PRJNA1146475 | ENA
GenomicsThe CDK12-INTAC Axis Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a a functional nuclear kinase complex, which has been reported to phosphorylate the carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) for transcriptional regulation and co-transcriptional RNA processing. However, the preci...
ORGANISM(S): Homo sapiens 
2023-05-19 | GSE217544 | GEO
GenomicsCatalytic-independent functions of INTAC confer sensitivity to BET inhibition [CUT&Tag]
Chromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. Pharmacologically targeting these regulators, particularly the transcription activating BET proteins,...
ORGANISM(S): Mus musculus 
2024-10-11 | GSE274475 | GEO
TranscriptomicsCatalytic-independent functions of INTAC confer sensitivity to BET inhibition [RNA-seq]
Chromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. Pharmacologically targeting these regulators, particularly the transcription activating BET proteins,...
ORGANISM(S): Mus musculus 
2024-10-11 | GSE274473 | GEO
UnknownCDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
Not available
S-EPMC10198629 | biostudies-literature
GenomicsThe small but versatile DSS1 protein is required for proper Integrator–PP2A function [ChIP-seq]
Integrator-PP2A (INTAC) is a highly modular complex orchestrating the transition of paused RNA polymerase II into productive elongation or promoter-proximal premature termination, with its loss resulting in transcription dysregulation and genome instability. Here, we identify human DSS1—a flexible 7...
ORGANISM(S): Homo sapiens 
2025-07-09 | GSE297001 | GEO
GenomicsThe small but versatile DSS1 protein is required for proper Integrator–PP2A function [CUT&Tag]
Integrator-PP2A (INTAC) is a highly modular complex orchestrating the transition of paused RNA polymerase II into productive elongation or promoter-proximal premature termination, with its loss resulting in transcription dysregulation and genome instability. Here, we identify human DSS1—a flexible 7...
ORGANISM(S): Homo sapiens 
2025-07-09 | GSE297000 | GEO
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