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GenomicsLeo1 is a Global Regulator of Heterochromatin Cis-spreading
Domains of heterochromatin play important roles in the maintenance and regulation of eukaryotic genomes. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates the existence of robust mechanisms that limit heterochromatin spreading and thereby a...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-61688 | biostudies-arrayexpress
ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
GenomicsLeo1 occupancy in presence of dengue virus NS5
Leo1 occupancy in presence of dengue virus NS5
PRJNA433884 | ENA
GenomicsLeo1 deletion reveals Set1-dependent transcription activation
Leo1 deletion reveals Set1-dependent transcription activation
PRJNA1295354 | ENA
UnknownLEO1 haploinsufficiency is associated with developmental delays and autism spectrum disorder.
Not available
S-EPMC12765696 | biostudies-literature
UnknownCDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
Not available
S-EPMC10198629 | biostudies-literature
GenomicsThe CDK12-INTAC Axis Modulates LEO1 Phosphorylation for Processive Transcription Elongation
The CDK12-INTAC Axis Modulates LEO1 Phosphorylation for Processive Transcription Elongation
PRJNA899509 | ENA
GenomicsLeo1 and Set1-mediated H3K4me3 contribute to sterol homeostasis in yeast [ChIPseq]
Leo1 and Set1-mediated H3K4me3 contribute to sterol homeostasis in yeast [ChIPseq]
PRJNA1024456 | ENA
UnknownLeo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence.
Not available
S-EPMC6636030 | biostudies-literature
GenomicsLeo1 deletion reveals Set1-dependent transcription activation [ChIP-Seq]
Leo1 deletion reveals Set1-dependent transcription activation [ChIP-Seq]
PRJNA1295895 | ENA
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