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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
TranscriptomicsTimecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)
The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the p...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42504 | biostudies-arrayexpress
ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039704 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039711 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
TranscriptomicsSubclone of resistant CT26 murine tumor shows high sensitivity to VA7 virotherapy: A novel system to study innate immunity and antigen dominance in oncolytic immuno-virotherapy
Recently, attenuated Semliki Forest virus vector VA7 completely eliminated type I interferon (IFN) unresponsive human U87 glioma xenografts while IFN responsive mouse GL261 and CT-2A gliomas proved refractory to the oncolytic virotherapy. Here we describe in two clones of a well established Balb/c m...
ORGANISM(S): Mus musculus 
2014-09-05 | E-GEOD-53001 | biostudies-arrayexpress
TranscriptomicsSuppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells
Certain oncolytic viruses exploit activated Ras signalling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identifi...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-31019 | biostudies-arrayexpress
TranscriptomicsInterferon-Gamma- and Murine-CMV-Activated Primary Macrophages
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42505 | biostudies-arrayexpress
ProteomicsComparative proteomics for identifying specific alterations within interferon response pathways in human glioblastoma multiforme and osteosarcoma cells
An acquisition of increased sensitivity of cancer cells to viruses is a common outcome of malignant progression that justifies the development of oncolytic viruses as anticancer therapeutics. Studying molecular changes that underlie the sensitivity to viruses would help to identify cases where oncol...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD022868 | Pride
Shotgun proteomics  glioblastoma multiforme  oncolytic virotherapy  interferon signaling alterations  jak/stat pathway 
TranscriptomicsRNA-seq of mouse intestinal organoids treated with interferon-gamma
We aimed to investigate gene expression changes in intestinal organoids from different mouse genotypes after treatment with interferon-gamma. Wild-type, villinCreER;KrasG12D/+;Trp53fl/flRosa26N1icd/+ (KPN), and villinCreER;Apcfl/fl;KrasG12D/+;Trp53fl/flTgfbrIfl/fl (AKPT) intestinal organoids were pl...
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-11769 | biostudies-arrayexpress
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