Ifit3 - OmicsDI

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Instrument Platform

Illumina HiSeq 2500 (3)
HPC services from the University of Granada (http://alhambra.ugr.es) (1)
Illumina MouseWG-6 v2 Expression BeadChip (1)
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Liquid Chromatography MS - alternating - hilic (1)

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Metabolite Name

2,3-DPG (1)
D-Ribulose-5-phosphate (1)
D-Glucose-1-phosphate (1)
Guanosine-diphosphate (1)
Flavin-mononucleotide (1)
Isocitric-acid (1)
Dihydroxyacetone-phosphate (1)
6-Phosphogluconic-acid (1)
Phosphoenolpyruvic-acid (1)
Fructose-1,6-bisphosphate (1)
C-di-AMP (1)
Fumaric-acid (1)
Citric-acid (1)
3-phenyllactic-acid (1)
Cysteic-acid (1)
Glucuronic-acid (1)
Triphosphate-guanosine (1)
2-Oxoadipic-acid (1)
D-Ribose-5-phosphate-disodium (1)
DL-Glyceric-Acid (1)
D-Mannose-6-phosphate (1)
Glycolic-acid (1)
L-2-Hydroxyglutaric-acid-disodium (1)
Alpha-Ketoglutaric-Acid (1)
L-Glutamic-acid (1)
Pyruvic-acid (1)
Itaconic-acid (1)
NicotinaMide-adenine-dinucleotide(NAD) (1)
Cis-Aconitic-acid (1)
Malic-acid (1)

First Public Date

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2024 (9)
2026 (8)
2021 (5)
2016 (3)
2014 (3)
2022 (2)
2017 (2)
2015 (2)
2023 (1)
2018 (1)
2013 (1)

Study type

Transcription profiling by array (20)
RNA-seq of coding RNA (6)
Methylation profiling by array (2)
RNA-seq of non coding RNA (2)
One-color microarray (1)
Animal - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
RIP-seq (1)
ChIP-seq (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)

Release Date

2022 (41)
2021 (37)
2024 (32)
2023 (29)
2020 (23)
2025 (22)
2016 (12)
2015 (10)
2014 (9)
2013 (9)
2017 (9)
2012 (7)
2026 (7)
2019 (7)
2010 (6)
2018 (5)
2011 (3)
2008 (2)
2009 (1)

Lab affiliation

Institute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich (3)
Cheeloo College of Medicine, Shandong University, Jinan 250002, PR.China. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China. Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei 230001, China. (1)
Cheeloo College of Medicine, Shandong University, Jinan 250002, PR.China. Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China. Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei 230001, China. (1)
Department of Medicine, Knight Cardiovascular Institute, Oregon Health & Sciences University, Portland, Oregon, USA (1)
Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK (1)
Icahn School of Medicine at Mount Sinai (1)
Infection and Immunity Program, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia (1)
Laboratory of Physical and Chemical Methods for Structure Analysis, V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia (1)
School of Pharmacy and Biomolecular Science, Royal College of Surgeons in Ireland, 123 St Stephen’s Green, Dublin 2, Ireland (1)
Shenzhen Center for Disease Control and Prevention (1)
Tuberculosis Research Program, Centenary Institute, Sydney, NSW, Australia; School of Medical Sciences, The University of Sydney, NSW, Australia (1)
laboratory of Physical and Chemical Methods for Structure Analysis, V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia (1)

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Targeting STK39 ameliorates cardiac remodeling by Improving Mitochondrial function through degradation of IFIT3

Pathological cardiac remodeling in response to sustained pressure overload is a pivotal process in the progression of heart failure (HF), yet the underlying molecular mechanisms remain incompletely understood, limiting therapeutic development. Here, we identify serine/threonine kinase 39 (STK39) ...

2026-09-28 | MTBLS15834 | MetaboLights

UBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma

Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...

ORGANISM(S): Homo sapiens (Human)

2024-01-26 | PXD039704 | Pride