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ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039704 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
ProteomicsUBE2O remodels the proteome during terminal erythroid differentiation
Terminal differentiation is characterized by a respecification of the global protein complement, as epitomized by erythrocytes, whose cytosol is ~98% globin. Remodeling of the proteome involves programmed elimination of generic cellular constituents in parallel with synthesis of cell-type-specific p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-08 | PXD005904 | Pride
Red blood cell Proteomics Ms3 Tmt Ube2o Proteasome Ubiquitin 
ProteomicsUBE2O targets a novel substrate IFIT3 for ubiquitination and degradation, impeding the interferon pathway activation and interferon sensitization in hepatocellular carcinoma
Abstract Rationale: Interferon (IFN) plays a key role in immunotherapy by acting through interferon-stimulated genes. Interferon resistance limits its efficacy. Ubiquitination modification of key proteins is a popular research direction in hepatocellular carcinoma (HCC), and it is also one of the im...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039711 | Pride
Ube2o Interferon pathway Hepatocellular carcinoma Ifit3 Interferon sensitivity 
TranscriptomicsA UBE2O-AMPKα2 axis that promotes tumor initiation and progression offers opportunities for therapy
UBE2O is localized in the 17q25 locus, which is known to be amplified in human cancers, but its role in tumorigenesis remains undefined. Here we show that Ube2o deletion in MMTV-PyVT or TRAMP mice profoundly impairs tumor initiation, growth and metastasis, while switching off the metabolic reprogram...
ORGANISM(S): Mus musculus 
2017-09-08 | GSE92919 | GEO
UnknownUBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Not available
S-EPMC6944706 | biostudies-literature
UnknownUBE2O remodels the proteome during terminal erythroid differentiation.
Not available
S-EPMC5812729 | biostudies-literature
UnknownMechanism of client selection by the protein quality-control factor UBE2O.
Not available
S-EPMC9526450 | biostudies-literature
UnknownUBE2O is a quality control factor for orphans of multiprotein complexes.
Not available
S-EPMC5549844 | biostudies-literature
UnknownUBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway.
Not available
S-EPMC8579295 | biostudies-literature
UnknownA UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Not available
S-EPMC5463996 | biostudies-literature
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