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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
TranscriptomicsRNA-seq of a human mammary fibroblast cell line in proliferation and IR-induced senescence with and without IL1-alpha treatment.
Transcriptomic analysis of inflammatory gene expression in a human mammary fibroblast cell line in proliferation and IR-induced senescence, with and without IL1-alpha treatment (10 pg/ml for 24 hours). Cells were induced into senescence by irradiation with 40 Gy of 120 kV X-rays and then incubated 9...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-16030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IL-1
Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcript...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9120 | biostudies-arrayexpress
TranscriptomicsExpression data from human amnion mesenchymal cells treated with interleukin-1-beta for 1hr and 8hr
Premature birth continues to be a challenging pregnancy complication, and a body of literature indicates that inflammation can contribute to premature delivery by converting a receptive uterine environment to a hostile one. Cytokines have been demonstrated to provoke up-regulation of inflammatory g...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26315 | biostudies-arrayexpress
UnknownIL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis.
Not available
S-EPMC3457944 | biostudies-literature
TranscriptomicsTranscriptional response of confluent human umbilical vein endothelial cells to stimulation with the related cytokines interleukin-1b or interleukin-33.
The similar response of endothelial cells to exogenous IL-33 or IL-1M-NM-2 prompted us to compare the genome-wide transcription profile of confluent human umbilical vein endothelial cell (HUVEC) cultures after 4 hours exposure to IL-33 or IL-1M-NM-2. Analysis of these data revealed a striking simila...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-37624 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thyroid cells exposed to INF-gamma and IL1-beta
Normal primary thyroid cells were incubated with , 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A a...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-5054 | biostudies-arrayexpress
GenomicsStat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework [IL1-R1_KO]
Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework [IL1-R1_KO]
PRJNA1230179 | ENA
TranscriptomicsH3-K27Ac Cut & Tag of primary human fibroblasts
Map H3-K27-acetyl marks associated with potential enhancers, promoters, and transcriptionally active chromatin in primary human fibroblasts from fetal lung (WI38), adult lung, adult abdomen, and adult breast under conditions of proliferation, X-irradiation, and treatment with 20 pg/ml IL1-alpha for ...
ORGANISM(S): Homo sapiens 
2026-07-09 | E-MTAB-17105 | biostudies-arrayexpress
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