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TranscriptomicsTranscription profiling by array of rat ventricular cardiac myocytes treated with interleukin 1 beta
Study of the effects of interleukin 1 beta on transcript expression in ventricular cardiac myocytes
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-MEXP-1960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal rat ventricular cardiac myocytes treated with interleukin 33 for 0.5, 1 or 2 hours
Study of the effect of interleukin 33 (IL33) on transcript expression in neonatal rat ventricular cardiac myocytes at 0.5, 1 or 2 h
ORGANISM(S): Rattus norvegicus 
2010-04-01 | E-MEXP-1912 | biostudies-arrayexpress
TranscriptomicsExpression data from human amnion mesenchymal cells treated with interleukin-1-beta for 1hr and 8hr
Premature birth continues to be a challenging pregnancy complication, and a body of literature indicates that inflammation can contribute to premature delivery by converting a receptive uterine environment to a hostile one. Cytokines have been demonstrated to provoke up-regulation of inflammatory g...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26315 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epidermal keratinocytes treated with IL-1
Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcript...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9120 | biostudies-arrayexpress
GenomicsInterleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory fun...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-75724 | biostudies-arrayexpress
TranscriptomicsInterleukin-1 signaling is involved in local self-renewal and maintenance of microglia
During early embryogenesis microglia arise from yolk sac progenitors populating the developing CNS, where they are maintained as tissue-resident macrophages throughout the organism’s lifespan. Here, we describe an experimental system that allows the specific conditional ablation of microglia in vivo...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-68376 | biostudies-arrayexpress
GenomicsInhibition of interleukin-1 receptor-associated kinase (IRAK)-4 provides partial rescue of interleukin-1 beta induced functional and gene expression changes in equine tendon cells.
Inhibition of interleukin-1 receptor-associated kinase (IRAK)-4 provides partial rescue of interleukin-1 beta induced functional and gene expression changes in equine tendon cells.
PRJNA1279161 | ENA
TranscriptomicsEffect of interleukin-1 and PDGF-DD on SMCs
This experiment tests the hypothesis that interleukin-1 promotes SMC phenotypic modulation to a distinct inflammatory state relative to the growth factor PDGF-DD. Cultured rat aortic smooth muscle cells were treated with IL-1b (2.5 ng/mL) or vehicle (0.1% BSA and 10 mM acetic acid) or PDGF-DD (30 ng...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-31080 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of the anti-inflammatory effects of PDTC on IL-6 signaling in HepG2 cells
Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts a wide range of cellular, physiological and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in STAT3 activation and downstream signaling. Here, a transcr...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-14632 | biostudies-arrayexpress
ProteomicsDataset of spatiotemporal influences of interleukin IL-1 family cytokine: Interleukin-33 on cellular signal transduction pathways
Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. IL-33 signaling, from the early signaling events triggered by the ligand-activated receptor to result in activation of early and late signaling events, such as proteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024385 | Pride
Mass spectrometry Cytokines Il-33 Monocytes 
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