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ProteomicsSpatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11
Appropriate cellular recognition of viruses is essential for the generation of effective innate and adaptive antiviral immunity. Viral sensors and their signalling components thus provide a crucial first line of host defence. Many exhibit subcellular relocalisation upon activation, triggering expres...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD051850 | Pride
Interleukin-11 Proteomics  systems virology  virus signalling  sendai virus  crtc 
TranscriptomicsThe Role of Interleukin-11 in the Development of the Autoimmune Response in Multiple Sclerosis
Our results introduce interleukin (IL)-11 as a new cytokine that may play a role in the development of the autoimmune response in patients with relapsing remitting multiple sclerosis (RR MS). IL-11 was found to be the highest up-regulated cytokine in the serum and cerebrospinal fluid (CSF) from pat...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-59085 | biostudies-arrayexpress
GenomicsCharacterization of Interleukin 11-producing fibroblasts that constitute a niche for tumor development [Agilent]
Characterization of Interleukin 11-producing fibroblasts that constitute a niche for tumor development [Agilent]
PRJNA703022 | ENA
GenomicsInterleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
PRJNA703020 | ENA
GenomicsCritical conditions for studying Interleukin-11 signalling in vitro and avoid experimental artefacts
Critical conditions for studying Interleukin-11 signalling in vitro and avoid experimental artefacts
PRJNA749029 | ENA
GenomicsInterleukin 11 in heart failure therapy
Based on data from mouse cardiac tissue snRNAseq, Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered
PRJEB67301 | ENA
TranscriptomicsCharacterization of Interleukin 11-producing fibroblasts that constitute a niche for tumor development [Agilent]
Interleukin (IL)-11 belongs to a member of the IL-6 family of cytokines and is involved in a variety of cellular responses. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generated Il11 reporter mice. IL-11+ cell...
ORGANISM(S): Mus musculus 
2021-02-22 | GSE141643 | GEO
GenomicsInterleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration [RNA-seq]
Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration [RNA-seq]
PRJNA903473 | ENA
GenomicsInterleukin 11 drives dermal fibroblast activation in mechanical stretch-mediated skin expansion
Interleukin 11 drives dermal fibroblast activation in mechanical stretch-mediated skin expansion
PRJNA1121315 | ENA
TranscriptomicsInterleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
Interleukin (IL)-11 is a member of the IL-6 family of cytokines and involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generated Il11 reporter mic...
ORGANISM(S): Mus musculus 
2021-02-22 | GSE164232 | GEO
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