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MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
TranscriptomicsDual RNA-sequencing of nontypeable Haemophilus influenzae and host cell transcriptomes reveals new aspects of host-pathogen interface
Characterization of host-pathogen interactions is critical for the development of next-generation therapies and vaccines. Classical approaches involve the use of transformed cell lines and/or animal models which may not reflect the complexity and response of the human host. We reconstituted the cili...
ORGANISM(S): Haemophilus influenzae 
2015-11-02 | E-GEOD-63900 | biostudies-arrayexpress
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
TranscriptomicsHost cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia
Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involveme...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-33731 | biostudies-arrayexpress
TranscriptomicsTranscriptome data of interacting Salmonella Typhimurium and human host cells
The poly(A)+ and poly(A)− fractions of interacting and non-interacting cells were used for distinct library preparation of interacting and non-interacting prokaryotic pathogen and eukaryotic host cells by deepSuperSAGE. Sequencing was performed with the Illumina HiSeq 2000 platform, and one point of...
ORGANISM(S): Salmonella enterica 
2015-05-12 | E-GEOD-61730 | biostudies-arrayexpress
TranscriptomicsRegulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM...
ORGANISM(S): Trypanosoma brucei brucei 
2013-12-16 | E-GEOD-46388 | biostudies-arrayexpress
ProteomicsQuantitative proteomics reveals metabolic reprogramming in host cells induced by trophozoites and intermediate subunit of Gal/GalNAc lectins from Entamoeba histolytica
The raw proteomics data in the manuscript "Quantitative proteomics reveals metabolic reprogramming in host cells induced by trophozoites and intermediate subunit of Gal/GalNAc lectins from Entamoeba histolytica".
ORGANISM(S): Homo Sapiens (human) 
2022-03-01 | PXD031959 | JPOST Repository
ProteomicsThe host factor: proteomic comparison of excretion/1 secretion products in Fasciola hepatica newly excysted juveniles (NEJ) derived from Lymnaea viatrix or Pseudosuccinea columella
The characteristics of parasitic infections are often tied to host behavior. Although most studies have investigated definitive hosts, intermediate hosts can also play a role in shaping the distribution and accumulation of parasites. This is particularly relevant in larval stages, where intermediate...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2019-04-30 | PXD011991 | Pride
Parasite-host interaction Fasciola hepatica Intermediate host Secretome 
TranscriptomicsInterleukin-10-anergized T-cell infusion provides immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Regulatory T cells restore tolerance in preclinical models of immune-mediated diseases and are therefore a promising alternative to conventional immune-suppression for preventing graft-versus-host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Adaptiv...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-21885 | biostudies-arrayexpress
TranscriptomicsTypes I GT1, II Me49, III CTGara strains - tachyzoite and Compound 1
Previous studies suggested that specific bradyzoite genes were differentially expressed in the three major lineages common to North America and Europe (Radke et al., 2006). In order to determine if these differences extended to the global transcriptome, we characterized whole-cell mRNA levels in bot...
ORGANISM(S): Toxoplasma gondii 
2010-05-19 | E-GEOD-16037 | biostudies-arrayexpress
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