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MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined multi-system intera...

2025-12-16 | MTBLS13513 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined mult...

2025-12-16 | MTBLS13512 | MetaboLights
MetabolomicsIdentification of urine metabolites in patients with interstitial cystitis using untargeted metabolomics (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001122 | MetabolomicsWorkbench
MetabolomicsIdentification of urine metabolites in patients with interstitial cystitis using untargeted metabolomics (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001121 | MetabolomicsWorkbench
MetabolomicsUrinary Volatile Compound, Associated with Chronic Inflammation In Interstitial Cystitis
Not available
ORGANISM(S): Homo sapiens 
ST000603 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation
Purpose: Evaluate gene expression profiles after inducing differentiation in cultured interstitial cystitis (IC) and control urothelial cells. Materials and Methods: Bladder biopsies were taken from IC patients and controls (women having surgery for stress incontinence). Primary cultures were gro...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11839 | biostudies-arrayexpress
TranscriptomicsInterstitial cystitis and antiproliferative factor treatment
Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Explanted bladder epithelial cells from patients with interstitial cystitis (IC) have been shown to differ from explanted control cells in several ways, including pr...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of bladder tissue of patients with interstitial cystitis
Interstitial cystitis (IC) is a progressive chronic bladder disease with an increasing incidence. Today, IC is diagnosed by subjective symptoms in combination with cystoscopic and histologic evidence. The ultimate goal is the development of a diagnostic assay for IC on a molecular level. A comparati...
ORGANISM(S): Homo sapiens 
2009-05-14 | E-GEOD-11783 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of urine sediment: evaluation for potential noninvasive markers of interstitial cystitis/bladder pain syndrome
Purpose: Determine if gene expression profiles in urine sediment could provide non-invasive candidate markers for painful bladder syndrome (PBS) with and/or without Hunner lesions. Materials and Methods: Fresh catheterized urine was collected and centrifuged from control (n = 5), lesion-free (n = 5)...
ORGANISM(S): Homo sapiens 
2012-02-06 | E-GEOD-28242 | biostudies-arrayexpress
Genomicsinterstitial cystitis
The Characteristic of Urinary Microbiota in Interstitial Cystitis by High Throughput Sequencing
PRJNA725997 | ENA
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