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MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined multi-system intera...

2025-12-16 | MTBLS13513 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined mult...

2025-12-16 | MTBLS13512 | MetaboLights
TranscriptomicsGene expression analysis of urine sediment: evaluation for potential noninvasive markers of interstitial cystitis/bladder pain syndrome
Purpose: Determine if gene expression profiles in urine sediment could provide non-invasive candidate markers for painful bladder syndrome (PBS) with and/or without Hunner lesions. Materials and Methods: Fresh catheterized urine was collected and centrifuged from control (n = 5), lesion-free (n = 5)...
ORGANISM(S): Homo sapiens 
2012-02-06 | E-GEOD-28242 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of bladder tissue of patients with interstitial cystitis
Interstitial cystitis (IC) is a progressive chronic bladder disease with an increasing incidence. Today, IC is diagnosed by subjective symptoms in combination with cystoscopic and histologic evidence. The ultimate goal is the development of a diagnostic assay for IC on a molecular level. A comparati...
ORGANISM(S): Homo sapiens 
2009-05-14 | E-GEOD-11783 | biostudies-arrayexpress
TranscriptomicsInterstitial cystitis and antiproliferative factor treatment
Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Explanted bladder epithelial cells from patients with interstitial cystitis (IC) have been shown to differ from explanted control cells in several ways, including pr...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation
Purpose: Evaluate gene expression profiles after inducing differentiation in cultured interstitial cystitis (IC) and control urothelial cells. Materials and Methods: Bladder biopsies were taken from IC patients and controls (women having surgery for stress incontinence). Primary cultures were gro...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11839 | biostudies-arrayexpress
TranscriptomicsCorrelation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome
Interstitial cystitis (IC) and bladder pain syndrome are terms used to describe a heterogenous chronic pelvic and bladder pain disorder of unknown etiology. The goal of this pilot study was to determine if gene expression profiling of bladder biopsy tissue from patients experiencing symptoms could b...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-57560 | biostudies-arrayexpress
ProteomicsPeptidomics analysis of urine from IC/BPS patients and healthy controls
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood etiology. A definitive diagnosis of IC/BPS can be challenging because many symptoms of IC/BPS are shared with other urological disorders. An analys...
ORGANISM(S): Homo sapiens (Human) 
2022-06-06 | PXD031843 | Pride
Urine Peptidomics Human Interstitial cystitis/bladder pain syndrome Mapp research network Ic/bps 
TranscriptomicsCorrelation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome
Interstitial cystitis (IC) and bladder pain syndrome are terms used to describe a heterogenous chronic pelvic and bladder pain disorder of unknown etiology. The goal of this pilot study was to determine if gene expression profiling of bladder biopsy tissue from patients experiencing symptoms could b...
ORGANISM(S): Homo sapiens 
2014-05-13 | GSE57560 | GEO
TranscriptomicsExpression data from mouse whole bladders of cyclophosphamide-induced cystitis
To analyze the gene expression of non-bacterial bladdder inflammation, mouse cyclophosphamide(CYP)-induced model of cystitis was adapted. Forty-eight hour after CYP or vehicle treatment, total RNA was extracted from CYP-treated group (CYP150) and control group (CYP0). We used microarrays to detail t...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-55986 | biostudies-arrayexpress
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