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MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
TranscriptomicsHuman notochordal cell transcriptome in the developing intervertebral disc
The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is believed to initiate intervertebral disc degeneration. Thus, defining the phenotype of human embryonic/fetal notochordal cells is essential for understanding their ro...
ORGANISM(S): Homo sapiens 
2018-08-29 | E-MTAB-6868 | biostudies-arrayexpress
TranscriptomicsThe long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. Howeve...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56081 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of the Developing Axial Skeleton: A role for Tgfbr2 in the Development of the Intervertebral Disc.
This SuperSeries is composed of the following subset Series: GSE18647: Gene expression in embryonic intervertebral disc and vertebrae. GSE18648: TGF-beta and BMP mediated gene expression in cultured sclerotome. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human intervertebral disc cells treated with varying osmolarity growth medium
Human intervertebral disc tissue was obtained from patients (average age 51 yrs) undergoing surgery for lumbar interbody fusion (n=3) or lumbar disc herniation (n=1). Cells were isolated by sequential pronase-collagenase digestion [3]. Cells were passaged twice in monolayer and suspended at a densit...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1648 | biostudies-arrayexpress
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsGene expression in embryonic intervertebral disc and vertebrae.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-ß superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue resul...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18647 | biostudies-arrayexpress
ProteomicsIntegrated with Proteome-sequencing, bulk RNA-sequencing and Single cell RNA-sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration
We selected humann intervertebral disc samples to perform proteomics analysis. There were 1 case of grade I , 1 case of grade II, 3 cases of grade Ⅲ and 3 cases of grade Ⅳ according to Pfirrmann classfication. RNA seqencing analysis and single-cell RNA sequencing were integrated with proteomics data...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040593 | Pride
Intervertebral disc degeneration Proteome-sequencing 
TranscriptomicsNoncoding RNAs in human intervertebral disc degeneration: an integrated microarray study
This SuperSeries is composed of the SubSeries listed below. Each of the SubSeries contained in this SuperSeries represents identical RNA samples used for hybridization to different array platforms. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-03 | E-GEOD-67567 | biostudies-arrayexpress
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