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TranscriptomicsCell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression.
Intracellular microbes have evolved efficient strategies for transitioning from one cell to another in a process termed intercellular transmission. Here we show that host cell transmission of the obligate intracellular parasite Toxoplasma gondii is closely tied to specific cell cycle distributions, ...
ORGANISM(S): Toxoplasma gondii 
2010-12-27 | E-GEOD-20480 | biostudies-arrayexpress
MetabolomicsA profile of the joint Toxoplasma-host infection metabolome finds broad changes to metabolism and discovers a novel parasite metabolic capability
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these, and carbon sources like glucose. from the host. While the importance of metabolism to Toxoplasma infection it obvious, it is unclear how Toxoplasma infection actually changes met...
2019-05-10 | MTBLS899 | MetaboLights
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
TranscriptomicsGlobal gene expression analysis of the zoonotic parasite Trichinella spiralis revealed novel genes in host parasite interaction
Trichinellosis of human and other mammals was caused through the ingestion of the parasiteM-oM-
ORGANISM(S): Trichinella spiralis 
2013-06-18 | E-GEOD-39151 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
TranscriptomicsDelineation of diverse macrophage activation programs in response to intracellular parasites and cytokines
To provide a global perspective on the relationships between macrophage activation programs and to understand how certain pathogens circumvent them, we used transcriptional profiling by genome wide microarray analysis to compare the responses of mouse macrophages following exposure to the intracellu...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-20087 | biostudies-arrayexpress
TranscriptomicsSimultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Leishmania (L) are intracellular protozoan parasites which are able to survive and replicate within the harsh and potentially hostile phago-lysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MM-NM-&) striving to eliminate the patho...
ORGANISM(S): Leishmania major 
2008-05-21 | E-GEOD-10442 | biostudies-arrayexpress
TranscriptomicsWhole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum
Transcriptional analysis of L. infantum promastigote compared to L. infantum intracellular amastigote and transcriptional analysis of L. infantum promastigote compared to L. infantum axenic amastigote. The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.infantum...
ORGANISM(S): Leishmania infantum 
2010-05-14 | E-GEOD-13983 | biostudies-arrayexpress
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
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