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MetabolomicsIdentification of traumatic intracerebral hemorrhage associated metabolites using untargeted metabolomics

This study applied serum metabolomics to compare 10 traumatic intracerebral hemorrhage (TICH) patients with 10 controls. LC-MS/MS identified 3,183 metabolites, with increased benzene derivatives, organic acids, and amino acids, and decreased fatty acids, glycerophospholipids, and sphingomyelins i...

2025-09-24 | MTBLS13032 | MetaboLights
MetabolomicsLC-MS-Based Serum Metabolomics Reveals Distinct Metabolic Signatures in Patients with Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality and disability. Using LC-MS, we profiled serum metabolites from 20 patients with and without ICH, identifying 3,178 metabolites. ICH samples were enriched in benzene derivatives (15.63%), organic acids (12.47%), ...

2025-09-24 | MTBLS13030 | MetaboLights
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
TranscriptomicsGut microbiota dysbiosis and neurological function recovery after intracerebral hemorrhage [16S rRNA-Seq]
We aimed to investigate the microbial community composition in patients with intracerebral hemorrhage (ICH) and its effect on prognosis. The relationship between changes in bacterial flora and the prognosis of spontaneous cerebral hemorrhage was studied in two cohort studies. Fecal samples from heal...
ORGANISM(S): Homo sapiens 
2024-08-22 | E-MTAB-14351 | biostudies-arrayexpress
GenomicsExamining Transcriptomic Alterations in Rat Models of Intracerebral Hemorrhage and Severe Intracerebral Hemorrhage
Examining Transcriptomic Alterations in Rat Models of Intracerebral Hemorrhage and Severe Intracerebral Hemorrhage
PRJNA1102337 | ENA
ProteomicsCirculating extracellular vesicles promote recovery in a preclinical model of intracerebral haemorrhage.
Extracellular vesicles (EVs) participate in cell-to-cell paracrine signaling and can be biomarkers of the pathophysiological processes underlying disease. In intracerebral hemorrhage (ICH), the study of the number and molecular content of circulating EVs may help elucidate the biological mechanisms ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-31 | PXD038630 | Pride
Extracellular vesicles Intracerebral hemorrhage Rat Proteomics Blood 
ProteomicsTargeted Deletion of EMMPRIN in Microglia/Macrophages Mitigates Neuronal Death in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high mortality and limited therapeutic options. Microglia and macrophages are myeloid cells that are rapidly recruited into ICH lesions where they contribute to secondary brain injury. However, the driver of myeloid cell neurotox...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD063205 | Pride
Intracerebral hemorrhage  emmprin  microglia/macrophages  matrix metalloproteinases  neuroprotection  regeneration 
ProteomicsProtein content of blood-derived extracellular vesicles. An approach to the pathophysiology of cerebral hemorrhage
Extracellular vesicles (EVs) participate in cell-to-cell paracrine signaling and can be biomarkers of the pathophysiological processes underlying disease. In intracerebral hemorrhage (ICH), the study of the number and molecular content of circulating EVs may help elucidate the biological mechanisms ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-17 | PXD037246 | Pride
Extracellular vesicles Intracerebral hemorrhage Rat Proteomics Blood 
GenomicsGenetics of Cerebral Hemorrhage with Anticoagulation (GOCHA)

This is a prospective, longitudinal cohort study of spontaneous ICH. Subjects were recruited from among consecutive patients ≥ 55 years old who presented with primary hemorrhage to the Massachusetts General Hospital or one of our off-site collaborators from 1999 to 2010. Potential subjects ...

phs000416.v1.p1 | EGA
ProteomicsPOTENTIAL ROLE OF CIRCULATING EXTRACELLULAR VESICLES IN RECOVERY AFTER INTRACEREBRAL HEMORRHAGE
The aim is to evaluate the potential role of circulating exosomes in endogenous mechanisms of cerebral repair after an intracerebral haemorrhage (ICH). We designed a a prospective observational study including patients suffering ICH. EVs were isolated from blood samples at 24 hours and 7 days after ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-13 | PXD048138 | Pride
Intracerebral hemorrhage Proteomics Extracellular vesicles Pathophysiology 
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