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TranscriptomicsExpression data from mouse small intestinal γδ intraepithelial lymphocytes
The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. In this study, we used microarrays to uncover the transcriptional re...
ORGANISM(S): Mus musculus 
2011-04-06 | E-GEOD-28437 | biostudies-arrayexpress
TranscriptomicsINTERLEUKIN 15-DEPENDENT T CELL-LIKE INNATE INTRAEPITHELIAL LYMPHOCYTES DEVELOP IN THE INTESTINE AND TRANSFORM INTO LYMPHOMAS IN CELIAC DISEASE
The nature of gut intraepithelial lymphocytes lacking antigen receptors remains controversial. Herein we showed that, in humans and in mice, innate intestinal intraepithelial lymphocytes expressing intracellular CD3 (iCD3+ innate IELs) differentiate along an Id2 transcription factor (TF)-independent...
ORGANISM(S): Homo sapiens 
2016-11-23 | E-MTAB-4960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine intraepithelial lymphocytes (IEL) vs. TCR ab+ CD8b+ and TCR gd+ cells
Mouse small intestine intraepithelial lymphocytes (IEL) that express a ab TCR and CD8aa homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to be defined. To gain insight into the nature of these cells, we performed global gene expression profiling using micr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5355 | biostudies-arrayexpress
ProteomicsComprehensive proteomics analyses of IL-15 driven activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T cells that protect the gut from pathogens and maintain intestinal homeostasis. The cytokine IL-15 is trans-presented by epithelial cells to IEL in complex with the IL-15 receptor α chain (IL-15Rα) and plays ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-10 | PXD025891 | Pride
Intraepithelial lymphocytes  interleukin-15  quantitative proteomics  coeliac disease  histone ruler  lfq 
TranscriptomicsComparison of gamma delta intraepithelial lymphocytes from DSS-treated and untreated colon
gamma delta intraepithelial lymphocytes were isolated from the colons of DSS-treated and untreated mice. Total RNAs were isolated and compared by Affymetrix DNA microarray. Duplicate comparisons were made between DSS-treated and untreated gamma delta intraepithelial lymphocytes.
ORGANISM(S): Mus musculus 
2008-12-18 | E-GEOD-13946 | biostudies-arrayexpress
ProteomicsTissue adaptation is the dominant driver of the proteomic landscape of intestinal intraepithelial lymphocytes
Intestinal intraepithelial T lymphocytes (T-IEL) patrol the single layer of epithelial cells lining the gut, and consist of both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural IEL, that are developmentally targeted to the intestine. To gain functional insights into...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-15 | PXD023140 | Pride
Tmt T cells Lymph nodes Lymphocytes Iel 
TranscriptomicsTranscription profiling of chicken intestinal intraepithelial lymphocytes following oral feeding of carvacrol cinnamaldehyde or capsicum oleoresin
One day-old broilers (Ross/Ross, Longenecker's Hatchery, Elizabethtown, PA) were housed in Petersime starter brooder units and randomly assigned to 4 groups (5 birds/group). Carvacrol (Nature Chemicals, Hamburg, Germany) and cinnamaldehyde (Alys Technologies SA, Bussigny-près-Lausanne, Switzerland) ...
ORGANISM(S): Gallus gallus 
2009-06-02 | E-MEXP-2204 | biostudies-arrayexpress
GenomicsMammary intraepithelial lymphocytes promote lactogenesis and offspring fitness
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness
PRJNA1173731 | ENA
GenomicsGene expression signatures for CD8αβ+ intraepithelial lymphocytes and CD8αβ+ splenocytes.
Gene expression signatures for CD8αβ+ intraepithelial lymphocytes and CD8αβ+ splenocytes.
PRJNA414538 | ENA
GenomicsGenome-wide maps of chromatin state in mouse small intestinal intraepithelial lymphocytes.
Genome-wide maps of chromatin state in mouse small intestinal intraepithelial lymphocytes.
PRJNA770876 | ENA
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