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GenomicsIntratumoral heterogeneity in cholangiocarcinoma
Intratumoral heterogeneity in cholangiocarcinoma
PRJEB63091 | ENA
GenomicsA study for intratumoral heterogeneity of glioblastoma
A study for intratumoral heterogeneity of glioblastoma
PRJNA1442795 | ENA
TranscriptomicsClonal heterogeneity in melanoma
Genetic heterogeneity is an important feature of solid tumors, however it is often assumed that most cancer cell lines are genetically homogeneous. A disparity in genetic complexity between cell lines and the disease they model could result in problems such as in vitro preclinical experiments overst...
ORGANISM(S): Homo sapiens 
2013-09-08 | E-MTAB-1753 | biostudies-arrayexpress
TranscriptomicsIntratumoral heterogeneity of prostate cancers
Copy number analyses of regionally separated intratumoral biopsies of prostate cancers. Intratumoral heterogeneity (ITH) leads to regional biases of the mutational landscape in a single tumor and may influence the single biopsy-based clinical diagnosis and treatment decision. To evaluate the extent ...
ORGANISM(S): Homo sapiens 
2014-01-18 | E-GEOD-54185 | biostudies-arrayexpress
TranscriptomicsSunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mRCC). 138 samples from patients with clear cell renal cell carcinoma, including biological replicates of nephrectomy samples. RNA extr...
ORGANISM(S): Homo sapiens 
2015-05-25 | E-GEOD-65615 | biostudies-arrayexpress
GenomicsA study for intratumoral heterogeneity of glioblastoma [scRNA-seq]
A study for intratumoral heterogeneity of glioblastoma [scRNA-seq]
PRJNA1445196 | ENA
TranscriptomicsRNA-seq of four human glioblastoma cell lines from heterogeneous U-343 cell system
Four glioblastoma cell line U-343 MG, U-343 MGa, U-343 MGa 31L, U-343 MGa Cl2:6 were derived form the same glioblastoma U-343. The RNA-seq was performed to identify their difference and better understand the glioblastoma heterogeneity.
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-8620 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cervical cancer patient biopsies to explore intratumour heterogeneity reveals that intratumor variation is low for most probe sets tested but that multiple biopsies are recommended for reliable estimates of gene expression
To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer. Experimental Design: A total of 33 biopsies were obtained from 11 patients, sampling between two and five different areas for each tumor.The extracted RNA was hybridized onto the Affymetrix U133 Plus ...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-5787 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of primary human glioblastomas
We report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, ...
ORGANISM(S): Homo sapiens 
2014-06-12 | E-GEOD-57872 | biostudies-arrayexpress
ModelsAlvarez2019 - A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity
This is a non-linear mathematical model of cancer immunosurveillance that takes into account intratumoral phenotypic heterogeneity, such as differential expression of cell surface receptors and growth factors, according to cell-mediated immune responses. The model describes phenomena that have also ...
2024-09-02 | BIOMD0000000790 | BioModels
Immuno-oncology 
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