Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
PML nuclear bodies (PML NBs) are membraneless nuclear compartments that contribute to intrinsic immune defenses against DNA viruses. Here, we identify the host transcription factor PATZ1 as a novel antiviral effector that forms condensates adjacent to PML NBs to suppress human bocavirus 1 (HBoV1) tr...
Systemic sclerosis (SSc) shows complex clinical manifestations including progressive skin and internal organ fibrosis. SSc can be divided into 'intrinsic subsets' by gene expression suggesting patient-specific heterogeneity in pathogenesis or temporal evolution of disease. Here we validate these su...
