Intrinsically disordered domain

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Drugging the intrinsically disordered transactivation domain of androgen receptor [LNCaP95]

PRJNA1134199 | ENA

Drugging the intrinsically disordered transactivation domain of androgen receptor [LNCaP]

PRJNA1134195 | ENA

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...

ORGANISM(S): Homo sapiens (Human)

2022-04-15 | PXD026263 | Pride

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

The membrane anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal i...

ORGANISM(S): Homo sapiens (Human)

2022-01-14 | PXD030006 | Pride

Cell transformation Cell signaling Protein kinase Intrinsically disordered region

Archaic chaos: intrinsically disordered proteins in Archaea.

Not available

S-EPMC2880407 | biostudies-literature

Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.

Not available

S-EPMC5314938 | biostudies-literature

Transcriptomic analysis to functionally map the intrinsically disordered domain of EWS/FLI

PRJNA505499 | ENA

The intrinsically disordered AR2 microdomain of RNase E binds mRNA translation initiation regions

PRJNA1415097 | ENA

Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin

PRJNA1071481 | ENA

Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity

In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...

ORGANISM(S): Mus musculus (Mouse)

2024-06-16 | PXD043586 | Pride

Tcf-1 T-cells L1 Transcription factor Idrs

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